SOURCES SOUGHT
66 -- Oroboros high-resolution respirometer to analyze the mitochondrial health of human subjects via in vitro assessment of mitochondrial function in aging human subjects.
- Notice Date
- 9/12/2013
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, 6001 Executive Boulevard, Room 4211 - MSC 9559, Bethesda, Maryland, 20892, United States
- ZIP Code
- 20892
- Solicitation Number
- SS3068391
- Point of Contact
- Mario D. Gray, Phone: 3014352238
- E-Mail Address
-
Mario.Gray@nih.hhs.gov
(Mario.Gray@nih.hhs.gov)
- Small Business Set-Aside
- N/A
- Description
- I. Introduction: This is a ‘Notice for Sources Sought' for commercial items prepared in accordance with the format in the Federal Acquisition Regulation (FAR) Part 10-Market Research, and, is supplemented with additional information. This is not a solicitation and request for proposals, proposal abstracts, and quotations. This is not an invitation for bids. This Government Issuing Agency and Contracting Office, on behalf of the Government Requiring Agency, seeks to obtain information regarding the interest and capability of any qualified business source to successfully meet the Government's requirements described in this notice. II. Business Interest and Capability: The purpose of this ‘Sources Sought Notice' is to allow any interested and capable business to identify itself and its capabilities. Thus, the Government is seeking capability statements from capable businesses including, but not limited to, the following types: 8(a), Veteran-Owned Small Business, Services-Disabled Veteran Owned Small Business, Historically Underutilized Business Zone Small Business, Small Disadvantaged Business, Women-Owned Small Business and Large Business. A business shall use its capability statement to demonstrate that: 1. The business possesses the capabilities to successfully meet the Government's requirements described in this notice; and, 2. The business is competitive in terms of quality, delivery, and market prices. Based on the business responses received, or not received, to this notice, the Government's requirements may be solicited as a 100% Full-and-Open Competition or a type of set-aside. III. Background: Currently, there is only respirometer available at the Baltimore Longitudinal Study (BLSA) at Harbor Hospital in Baltimore City, MD at Harbor Hospital to assess mitochondrial function in BLSA subjects. This unit can only handle 2 samples, severely limiting the number of subjects that can be tested. The additional respirometer is critical because the volume of tissue samples from human subjects is increasing dramatically. Thus, the acquisition of an additional respirometer will double the number of samples that can be assayed which critical since the volume of samples is greatly increasing. IV. Purpose/Objective/Scope: Mitochondria provide energy to mammalian cells including humans. A decline in mitochondrial function with age is believed to play a critical role in human diseases including sarcopenia and cardiovascular disease. The aim of this project is to determine the changes in mitochondrial function in muscle tissues of subjects in the Baltimore Longitudinal Study of Aging (BLSA) as they age and experience muscle loss as well as in other studies such as the Resveratrol and Cardiovascular Health in the Elderly trial (REACHE). The tissue biopsies taken from each subject at different time intervals will be assayed in vitro with the respirometry equipment being purchased. The volume of samples to be assayed using this equipment and our existing respirometer will greatly increase as we plan to conduct these assays on all human subjects in NIA IRP studies. Specifically, new equipment will be utilized to assess mitochondrial function via in vitro assays of muscle fibers donated by BLSA participants and other studies involving human subjects, notably the Resveratrol And Cardiovascular Health in the Elderly: REACHE Trial, of various ages. Age-related muscle loss is known as sarcopenia, meaning loss of muscle flesh. The BLSA and the study of sarcopenia in its subjects is a critical long term objective. The addition of this equipment will serve to contribute to the mission of the National Institute on Aging Intramural Research Program (NIA, IRP). V. Government's Requirements and Need Description: The business shall demonstrate detailed knowledge, skill and capabilities regarding the elements and features essential to meet the Government's requirements and need description as follows: - The Government needs an Oroboros high-resolution respirometer to analyze the mitochondrial health of human subjects via in vitro assessment of mitochondrial function in aging human subjects which: 1. Capability for simultaneous measurements with such high resolution and sensitivity. 2. Capability for use via in vitro assays that measure dissolved oxygen in tissue samples and is equipped for dual monitoring of samples and parameters and capability of detecting signals from samples less than 1 milligram in size. 3. Possesses a Flourescence LED unit enabling simultaneously analysis of multiple parameters including reactive oxygen species production, mitochondrial membrane potential and oxygen consumption. VI. Period of Performance or/and Delivery Information: Delivery Within: 8 Weeks After Receipt of Order. VII. Response: 1. Any interested and capable business shall submit its capabilities statement tailored to this ‘Sources Sought Notice'. The capabilities statement shall clearly define the interested business' capabilities using an Adobe PDF or Microsoft Office document which limited to 15 pages total. Any interested and capable business shall ensure that its response is accurate, complete, and sufficiently detailed to allow the Government to assess the business' capabilities. The interested business' capabilities statement shall include the interested business' accurate and complete DUNS Number, Legal Business Name, "Doing Business as Name", Physical Address, Point of Contact Information, applicable North American Industry Classification System Code, Type of Business, and Business Size. Responses shall be submitted ONLY to Mario.Gray@nih.hhs.gov by the closing date of this ‘Sources Sought Notice'. 2. Respondents who believe that they are manufacturers or authorized resellers of the items specified in this announcement must provide as part of their response: 1. product, catalog, model, and/or part number(s); 2. product description(s); 3. all relevant information and documentation that the item(s) offered meet(s) the specification requirements: salient physical, functional, and performance characteristics, as specified in the specification requirements and item description section; 4. quantity; 5. estimated price or cost; 6. shipping, handling, and/or installation charges; and, 7. delivery date after receipt of order. VIII. Legal Considerations: The Government is under no obligation to acknowledge receipt of a response or to provide feedback to a response to this ‘Sources Sought Notice". This notice does not obligate the Government to award a contract or order to a respondent to this notice or pay for the information provided by a respondent to this notice. A respondent whom provides classified, confidential, proprietary, or/and sensitive information, does so entirely at its own risk and without the Government being subject to liability. The Government reserves the right to use information provided by any respondent for any purpose the Government deems appropriate and lawful. The Government reserves the right to use information provided by any respondent for any later announcement, notice, solicitation or/and synopsis.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-01/SS3068391/listing.html)
- Record
- SN03185251-W 20130914/130912235246-64b26ef66a8cf6ff940475cdd013584d (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |