SOLICITATION NOTICE
65 -- OMNI cohort genotyping - Package #1
- Notice Date
- 8/27/2013
- Notice Type
- Presolicitation
- NAICS
- 325199
— All Other Basic Organic Chemical Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- HHS-NIH-NHLBI-CSB-(HL)-2013-221-DDC
- Archive Date
- 9/15/2013
- Point of Contact
- Deborah - Coulter, Phone: (301) 435-0368
- E-Mail Address
-
dc143b@nih.gov
(dc143b@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Justification and Approval (J&A) INTRODUCTION: THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). The National Heart, Lung, and Blood Institute (NHLBI) Office of Acquisition (OA) on behalf of the of the Framingham Heart Study (FMS), (NHLBI), intends to negotiate and award a purchase order on a noncompetitive sole source basis without providing for full and open competition to Affymetrix, 3420 Central Expressway, San Clara, CA 95051 to procure OMNI cohort genotyping. Procurement: The vendor will: - send out bar-coded sample plates to receive DNA aliquots - receive DNA aliquots in plates - follow good lab practices to avoid sample mix-ups from the point of receipt - conduct genotyping in their labs on all 900 samples following their approved protocol - conduct sample and variant QC analyses including negative control samples, positive control samples, sample and variant call rates, analysis of duplicate samples, Mendelian error checks, gender-mismatch checks, measurements of genotype quality including Hardy-Weinberg Equilibrium calculations - in cases of sample QC failures or poor quality results, repeat data acquisition if necessary with new DNA aliquots up to 3 times - store raw and processed data on vendor purchased hard drives - ship vendor hard drives to the Government and verify delivery - provide answers to technical support questions following delivery of results - provide access to any available bioinformatics and annotation resources typically provided to customers using the product The desired results for the Government Background: Genotyping of 900 DNA samples with a whole-genome SNP mapping genotyping product is required. This product must include modern content (based on information from major population genetics databases in the last 1 year) since this content has been rapidly changing. The content must also include design aimed at genetic mapping in diverse population samples. The content should include rare variation recently discovered, as well as functional ("loss of function") genetic variation. This is to improve the discovery of high impact large effect genetic variants. Also, it may provide compatibility with other project effort in different DNA samples which have focused on rare variation content (exome sequencing and exome chip projects). Purpose and Objective: The objectives are for the contractor to complete DNA genotyping with a product that meets specifications, and to complete quality control checks and re-genotype any failed samples. This will result in a large computer dataset which reflects a data matrix approximately 900 X 580,000 (522 million entries) of individuals and their genotypes for specific genetic markers, and will be returned by the vendor to the government. Anticipated Delivery: All genotyping and QC will be completed and delivered by November 30th 2013 Justification: Refer to attached Justification and Approval Regulatory Authority: This acquisition is conducted under the authority of the Federal Acquisition Regulations (FAR) Subpart 13.106-1(b) Soliciting from a single source, only one responsible source and no other supplies or services will satisfy agency requirements. Government Responsibilities: The Government will provide DNA samples from an existing biobank laboratory Reporting Requirements and Deliverables: The vendor will confirm receipt of DNA samples. The vendor will provide periodic updates (bi-weekly) on the sample progress and genotyping. The vendor will provide an initial overview of genotyping and QC results when completed. If samples fail QC vendor will discuss with the Government subsequent course of actions including potential re-genotyping of samples. Once final genotyping and QC is deemed complete vendor will confirm shipping and receipt of hard drives containing the data product. Inspection and Acceptance Requirements: The Government investigator (Andrew Johnson) will inspect data QC reports from the vendor. These will include primary measures of overall sample call rates (% success) and variant call rate rates (% success), as well as specific analysis outcomes such as suspected gender mismatches; Mendelian inconsistencies based on pedigree data; positive, negative and duplicate control samples; monomorphic rates; and Hardy-Weinberg equilibrium outliers ADDITIONAL INFORMATION Industry Classification (NAICS) Code is 325199, All Other Basic Organic Chemical Manufacturing Services and the Small Business Size Standard is 1000 employees. The acquisition is being conducted under FAR Part 13, simplified acquisition procedures, therefore the requirements of FAR Part 6 B Competitive Requirements are not applicable (FAR Part 6.001). The resultant Contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 05-69 (August 1st 2013). This requirement is under the SAT of $150,000.00. This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov." A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement. All responses must be received by August 31, 2013, 9:00 am eastern standard time and must reference synopsis number HHS-NIH- NHLBI-CSB-(HL)-2013-221-DDC, may be submitted to the National, Heart, Lung and Blood Institute, Office of Acquisition, COAC Services Branch, 6701 Rockledge Drive, Suite 6142, Bethesda, Maryland 20892-7902, Attention: Deborah Coulter. Response may be submitted electronically to coulterd@nhlbi.nih.gov. Faxes will not be accepted. Responses will only be accepted if dated and signed by an authorized company representative. "All responsible sources may submit a bid, proposal, or quotation which shall be considered by the agency."
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