SOURCES SOUGHT
66 -- Brand Name DeltaVision OMX with Blaze SIM Module & Elite Imaging System for the National Cancer Institute (NCI), Center for Cancer Research (CCR)
- Notice Date
- 7/19/2013
- Notice Type
- Sources Sought
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 9609 Medical Center Drive, Room 1E128, Rockville, Maryland, 20852, United States
- ZIP Code
- 20852
- Solicitation Number
- NCI-130078-HN
- Archive Date
- 7/27/2013
- Point of Contact
- Huy Nguyen, Phone: 2402765570, Seena Ninan, Phone: 240-276-5419
- E-Mail Address
-
anh-huy.nguyen@nih.gov, ninans@mail.nih.gov
(anh-huy.nguyen@nih.gov, ninans@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This Small Business Sources Sought Notice (SS) is for information and planning purposes only and shall not be construed as a solicitation or as an obligation on the part of the National Cancer Institute (NCI). The purpose of this Sources Sought Notice is to identify qualified small business concerns including 8(a), HUBZone or Service-Disabled Veteran-owned business concerns that are interested in and capable of performing the work described herein. The NCI does not intend to award a contract on the basis of responses received nor otherwise pay for the preparation of any information submitted. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice. This requirement is assigned North American Industry Classification System (NAICS) code 334516 with a size standard of 500 employees is being considered. As a result of this Sources Sought Notice, the NCI may issue a Request for Quotation (RFQ) through FedBizOpps. THERE IS NO SOLICITATION AVAILABLE AT THIS TIME. However, should such a requirement materialize, no basis for claims against NCI shall arise as a result of a response to this Sources Sought Notice or the NCI's use of such information as either part of our evaluation process or in developing specifications for any subsequent requirement. The purpose of this acquisition is to purchase the DeltaVision OMX with Blaze SIM Module and Elite Imaging System. Laboratories within the Laboratory of Biochemistry and Molecular Biology (LBMB) investigate many aspects of chromosome biology, including heterochromatin formation, chromosome segregation, regulation of genome stability, and maintenance of telomeres. Particularly relevant to this acquisition is the focus on the cell biology of chromosome structure and telomere biology. Telomeres are specialized protein-DNA structures located at the ends of chromosomes. Proper telomere maintenance is critical for many fundamental cellular processes, such as chromosome segregation, stem cell proliferation, and prevention of translocations that can lead to cancer. In order to investigate telomere function as well as other aspects of chromosome biology, such as chromosome organization, compaction, and structure, a high speed, super-resolution microscope capable of multiple imaging applications is needed to meet the goals of the laboratory. The system will be used to investigate the underlying mechanisms of chromosome biology, including heterochromatin formation, chromosome segregation, chromosome organization, and telomere maintenance, and to discover the causative effect of defects in these fundamental processes, in particular as they pertain to the initiation of cancer cell states. The DeltaVision OMX with Blaze SIM Module and Elite Imaging System possesses the following salient characteristics: •Equipped with 4 laser excitation optic assemblies (405, 488, 568 and 642nm) and 4 sCMOS cameras capable of wide field imaging at 400 frames per second. •Provide the capability for rapid automated switching between illumination channels as well as the ability to image either simultaneously or sequentially. •Microscope stage must be equipped with precision control motors to allow for precise stage control and stability for 3D imaging. •Ability to image thousands of specifically designated points of interest in a single time-lapse experiment. •The system shall be housed in an enclosure that can act as a darkroom, provide HEPA air filtration and positive pressure to reduce dust contamination of optical elements. Environmental control of temperature and CO2 conditions is also required for live cell imaging. •The system shall include two workstations - one dedicated to image acquisition and the other for image reconstruction and analysis - with all necessary software included. •The system should be equipped with a hardware autofocus module. •For structured illumination imaging, the system shall be able to acquire a 1um stack in 1 second per channel to enable imaging of live samples in super-resolution. In structured illumination mode, the system shall be capable of automatically optimizing X/Y/Z resolution for each channel acquired and should achieve 100-160nm resolution in X/Y and 280-350nm resolution in Z. •For 3D high resolution image acquisition, the system shall be capable of imaging at 400 frames per second in up to 4 channels simultaneously. •The system shall be equipped with software for deconvolution of wide field images. •The system shall include a fully integrated high resolution widefield fluorescence imaging system optimized for live cell imaging. •Stage mapping to the system used for 3D structural illumination is required for full integration and use as a spotting scope. This feature shall include a motorized X/Y/Z stage capable of marking designated points of interest. •The system shall include a 7 channel solid state illumination module with excitation for DAPI, CFP, FITC/GFP, TRITC, mCherry, Cy5. •A workstation shall be provided for image acquisition control and with software for quantitative iterative deconvolution, visualization, and quantification tools How to Submit a Response: 1.Page Limitations: Interested qualified small business organizations should submit a tailored capability statement for this requirement not to exceed 10 single sided pages including all attachments, resumes, charts, etc. (single spaced, 12 point font minimum) that clearly details the ability to perform the requirements of the notice described above. All proprietary information should be marked as such. Responses should include a minimum of a two pages demonstrating experience over the past two years meeting the requirements of this notice. Statements should also include an indication of current certified small business status; this indication should be clearly marked on the first page of your capability statement (preferable placed under the eligible small business concern's name and address). Responses will be reviewed only by NIH personnel and will be held in a confidential manner. 2.Due Date: Capability statements are due no later than 4:00 a.m. EST on July 29, 2013. 3.Delivery Point: All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the unique specifications described herein. Written responses can be emailed to Huy Nguyen, Contract Specialist at anh-huy.nguyen@nih.gov or mailed to the address located under Point of Contact. All questions must be in writing and can be faxed to (240) 276-5401 or emailed. A determination by the Government not to compete this requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference number SS-NCI-130078-HN on all correspondence. Disclaimer and Important Notes: This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization's qualifications to perform the work. Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, an RFQ may be published on FedBizOpps. However, responses to this notice will not be considered adequate responses to a solicitation(s). Point of Contact: Inquiries concerning this Notice may be direct to: Huy Nguyen 9609 Medical Center Dr, Room 1E154 Bethesda, MD 20892-9705 anh-huy.nguyen@nih.gov
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-130078-HN/listing.html)
- Record
- SN03121991-W 20130721/130719234606-3f637ee920102eb40731d536b011801f (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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