SOLICITATION NOTICE
B -- Genetic Factors in Taste Perception and Tobacco Usage
- Notice Date
- 5/3/2013
- Notice Type
- Presolicitation
- NAICS
- 541690
— Other Scientific and Technical Consulting Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Office of Administration, 6011 Executive Blvd, 5th Floor, Rockville, Maryland, 20852-3804, United States
- ZIP Code
- 20852-3804
- Solicitation Number
- NIHOD2013427
- Archive Date
- 9/1/2013
- Point of Contact
- Sheryn N. Etti, Phone: 3015943560
- E-Mail Address
-
ettis@mail.nih.gov
(ettis@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Institutes of Health (NIH), Office of the Director, on behalf of the National Institute of Deafness and other Communication Disorders (NIDCD), intends to solicit and negotiate on a non-competitive basis with only one source, the University of Texas Southwestern Medical Center, Dallas, Texas. The cited authorities are 41U.S.C. 253(c)(1), as set forth in FAR 6.302-1. The anticipated period of performance is a one-year base period with two (2) one-year option periods. The Food and Drug Administration (FDA), Center for Tobacco Products (CTP) via the NIH Intramural Center for Tobacco Regulatory Science (ICTRS) will provide support for this project, "Genetic factors in taste perception and tobacco usage." This project is a collaborative investigation into the role of inherited differences in taste perception in tobacco use, taking advantage of our substantial experience in the genetics of human taste perception and the role of taste variation in tobacco use. During the course of this project, we will catalog and quantify the variation in genes that encode the taste perception system and use these to measure association between taste-specific genetic variants and tobacco use in a large multi-ethnic U.S. population sample. This will include studies of the genes encoding receptors for menthol, bitter, sweet and savory, sour, and burning tastes. It also includes genes encoding the downstream signaling components in taste cells. These variants will be assayed in study population that has been well characterized for cardiovascular risk factors including tobacco use. The overall goal of this project is to determine whether variation in the genes encoding the menthol and other taste receptors is associated with tobacco use, including the use of mentholated cigarettes. The University of Texas Southwestern Medical Center owns and possesses samples from the Dallas Heart Study population. There is no other population sample of comparable size and ethnic composition that has DNA samples and tobacco use data available. The use of the University of Texas Southwestern Medical Center DNA sequencing core facility is mandated by UT Southwestern, who is the sole owner of the Dallas Heart Study DNA samples. This organization has the resources to perform whole-exome DNA sequencing and bioinformatic analyses of the existing single nucleotide polymorphism (SNP) DNA sequence variation in this data.   Organizations having demonstrated experience in performing the above requirements are invited to submit capability statements. Capability statements must document the following: 1) Perform bioinformatic analyses of the existing single nucleotide polymorphism (SNP) DNA sequence variation data in the identified study population (approximately 20,000 SNP loci per individual) to determine the haploypte structure and search for associations with 14 existing tobacco use measures in these individuals. 2) Perform whole-exome DNA sequencing in study population subjects who represent the highest 12.5% and lowest 12.5% of tobacco use. Exome capture will be performed using the Illumina TruSeq exome selection/enrichment system and sequencing will be performed on an Illumina HiSeq 1000 instrument to generate >50-fold coverage of the exonic sequences in these individuals. Quality control measures will be performed on Agilent 2100 BioAnalyzer and Applied Biosystems quantitative polymerase chain reaction (qPCR) instruments. 3) Gather and analyze data on four aspects of mentholated or other flavored tobacco use of individuals described in Section 2 above; existing genotypes typed across the genome in the identified study population will be evaluated directly. 4) Data will be managed and stored in ANSI-compliant PostgreSQL relational database maintained at the contractor's location, with state-of-the-art protection of anonymity and confidentiality of all human subjects. 5) Perform analysis of association between genetic variants discovered using whole exome sequencing and tobacco use, including use of flavored tobacco products, using linear regression with covariates. 6) Hire well qualified postdoctoral level staff or equivalent to lead data organization, storage, and analysis efforts at the contractor's site. 7) Provide regular scientific reports to NIDCD collaborators, and budget reports as required by the NIH, Food and Drug Administration, and others. 8) Participate in writing, submission, and editing of manuscripts that report study results in peer-reviewed scientific literature. Capability statements submitted in response to this notice that do not provide sufficient information for review will not be considered. This is NOT a Request for Proposals (RFP), and responses should NOT include budgetary information. Respondents to this notice shall provide capability statements (one original and three (3) copies) no later than 12:00 p.m. EST on May 20, 2013 to Sheryn N. Etti (Ref. NIHOD2013427), National Institutes of Health, Office of Acquisitions, 6011 Executive Blvd., Room 541E (MSC 7663) Bethesda, MD 20892-7663. PLEASE NOTE: If you are using a courier service, Federal Express, or UPS, the city, state, and zip code should read ROCKVILLE, MD 20852). Please be aware that the U.S. Postal Service's "Express Mail" DOES NOT deliver to the Rockville, Maryland address AND delivery to the Bethesda, Maryland address will result in a delayed delivery to our office in Rockville, MD (up to 3 - 5 days). Email and facsimile copies will not be accepted. Note : This synopsis follows Sources Sought Notice HHS-NIH-OD-OLAO-SBSS-13-003 that was released on April 16, 2013. Disclaimer : This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Respondents are advised that the Government is under no obligation to acknowledge receipt of information received or provide feedback to respondents with respect to any information submitted.
- Web Link
-
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- Record
- SN03052096-W 20130505/130503234227-9a3d452526b29881d8b5b02322ba3fca (fbodaily.com)
- Source
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