SOURCES SOUGHT
66 -- Confocal Microscope with CPARS capability
- Notice Date
- 12/14/2012
- Notice Type
- Sources Sought
- NAICS
- 333314
— Optical Instrument and Lens Manufacturing
- Contracting Office
- Department of Health and Human Services, Food and Drug Administration, Office of Acquisitions and Grants Services, 3900 NCTR Road, HFT-320, Bldg 50 | Rm 421, Jefferson, Arkansas, 72079, United States
- ZIP Code
- 72079
- Solicitation Number
- Confocal1113350
- Archive Date
- 1/5/2013
- Point of Contact
- Marcia O Park, Phone: (870) 543-7405
- E-Mail Address
-
marcia.park@fda.hhs.gov
(marcia.park@fda.hhs.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a Sources Sought Notice to determine the availability and capability of potential Small Business Manufacturers or Small Businesses capable of supplying a U.S. made product of a small business manufacturer or producer. This notice is for planning purposes only, and does not constitute an Invitation for Bids, a Request for Proposals, Solicitation, Request for Quotation, or an indication the Government will contract for the items contained herein. This notice is not to be construed as a commitment on the part of the Government to award a contract, nor does the Government intend to pay for any information submitted as a result of this notice. The applicable North American Industry Classification System (NAICS) code is 333314, Optical Instruments and Lens Manufacturing and the size standard is 500 employees. The U. S. Food and Drug Administration (FDA) is seeking to identify sources that can provide a confocal microscope system with the salient characteristics listed below. Background The Microscopy and Imaging Core Facility of the Food and Drug Administration's (FDA) Center for Biologics Evaluation and Research (CBER) supports all FDA scientists and laboratories for their morphological studies and light microscopic imaging. The main projects of the facility are analyzing the host - pathogen (e.g., virus, bacteria) interaction using cultured cells and tissue or small animals in immunological responses and vaccine related studies. Nonlinear Microscopy (e.g., Coherent Anti-Stokes Raman Scattering (CARS), Stimulated Raman Scattering (SRS), Multi-Photon (MP), and Second Harmonic Generation (SHG) is an emerging technology that is being used as a scientific tool in the facility's research programs. CARS microscopy has ability to analyze cell or tissue by visualizing its own unique molecular vibrations without labeling. Combination of Fluorescence and CARS microscopy enables the monitoring of host-pathogen interactions in real time. Based on the applications that core users request, the core facility is seeking a CARS/MP microscope imaging system that has the following modules and applications to accommodate investigators broad imaging needs which are critical for research /review programs. In addition, the program requires the super resolution microscopy component for the ability to identify very tiny objects to assist in visualization of pathogens in cells, tissues or live animals. 1. System shall have nonlinear microscopy capability, including picosecond CARS, MP, SRS and SHG for analysis of the various vibration of molecules in unlabeled or labeled tissues or specimens 2. System shall be a high resolution, high sensitivity and high speed imaging system with efficient multicolor image acquisition for labeled and unlabeled cells, tissue samples and animals. 3. System shall have capability for 4 channel intra-vital Multi-photons with Second Harmonic Generation (SHG) multicolor microscopy imaging. 4. System shall be equipped with at least 2 non-descanned detectors (NDD), 2 Reflected and 1 transmitted external light detector for sensitive backward direction (epi) and forward CARS with multicolor MP and SHG imaging. 5. The system shall have Infra Red laser based differential interference contrast (IR-DIC) Imaging detector to visualize morphological image from various biological specimens. 6. The CARS laser system shall be tunable, ranging the wavelength of a minimum of 780 to 940 nm, and generate output with a bandwidth of 5-6 picoseconds for optimum CARS signal detection with wave numbers between 1200-3500 (cm-1). The system shall also be equipped with a Chirp spectral focus function. 7. System shall have a built-in Raman Library for tuning desired wave numbers for control Stokes and Pump beams. 8. System shall have minimum 12k Hz resonant scanner for image acquisition to capture fast event in biological specimen (200 fps at 512/512) 9. System shall have minimum image format of 8192 x 8192 for low magnification objective lens. 10. The MP/IR laser system shall have group-velocity dispersion (GVD) compensation system for deep tissue imaging. 11. System shall have dual (fixed and piezo) stage for intra-vital and conventional microscopy use. 12. System shall have molecular mobility assay such as fluorescence recovery after photo-bleaching (FRAP) and molecular interaction assay modules such as Forster resonance energy transfer (FRET), as well as spectral and fluorescent lifetime (FLIM) imaging. 13. System shall have ability to track/visualize both very fast and slow movement particles, such as fluorescently labeled peptide or viral particles and ability for flexible/variable scan speed (40-428 fps) depending on the imaging project. 14. System shall have lambda spectral scan capability for detecting full emission wavelength spectra/curve to visualize dye separation and ready for multicolor analysis on the handling of new dye, fluorochrome or fluorescence proteins. 15. System shall have the following lasers: White light laser (tunable 1nm between 470-670 nm), UV 405, Argon (458, 488, 496, and 514 nm) 561 and 633 nm, IR, CARS 16. Laser system shall have capability to deliver the pulse to the deep tissue for multi-photon, SHG and CARS imaging, e.g., mouse lymph nodes, spleen, lung, intestine, muscle, skin and brain, Drosophila and C. Elegance. 17. System shall be upright microscope, ready for applications of deep tissue or live animals equipped with large environmental chamber with CO2 and temperature control modules (37 degrees C) 18. System shall be equipped with mouse specific isoflurane gas anesthesia system for MP CARS intra-vital microscopic imaging 19. System shall have high content microscopy capability, ready for fully automated/autofocus large tile scan or 5D multi point time lapse imaging on many vaccine and drug candidate screening applications 20. System shall have capacity to handle large number of light and fluorescent slide samples, (core requires slide scanner for high content automated image acquisition system for pre-screening purposes.) System shall have automated slide loader and Dynamic Focus Tracing module with single 20x objective lens and shall be able to scan thick tissue section with 100 various depths in high speed. 21. System shall be able to visualize viruses, bacteria, cell receptors or nanoparticles and shall have ability to perform at lease three channel super resolution microscopy capabilities with 20 nm resolution with real time visualization of influenza A virus, West-Nile, Dengue, Vaccinia, and mumps viruses without image post processing. System shall be less than 20 nm for 10 minutes and must display localized signals/points in real time. 22. System shall have anti-vibration table which actively minimizes any vibration from the environment. 23. Contractor shall provide hardware and software system updates and upgrades as they become available for period of 12 months from date of installation. 24. On-site Installation and training 25. Contractor shall provide technical support (troubleshooting) via email or telephone for 12 months from date of installation 26. Contractor shall provide not less than a one year Warranty to include maintenance and alignment of attached lasers 27. Maintenance agreements for up to four option years to include all labor, parts and one preventive maintenance visit per year as well as telephone and/or email technical support for lasers and microscope. Parties submitting capability statements shall be advised that generic capability statements are not sufficient for effective evaluation of respondents' capacity and capability to provide the required specified equipment. Respondents should submit their capability statements not exceeding fifteen (15) pages in length, excluding standard brochures. Potentials contractors must indicate business size, proof of any set-aside certification and company's DUNS number and provide a contact name, the mailing address, phone number, email address of point of contact and reference CONFOCAL 1113350. Identification of the firm's GSA Schedule contract(s) by Schedule number and contract number that maybe applicable to this potential requirement are also requested. Contractor shall provide any descriptive literature necessary for the government to determine whether the product offered meets the technical requirements including: technical specifications, descriptive literature, brochures and other information which demonstrates the capabilities of the contractor's equipment. Interested Parties must respond with capability statements in person on or before December 21, 2012 by 1:00 PM (Central Time) Jefferson, Arkansas, at the Food and Drug Administration, Office of Acquisitions and Grants Services, Field Operations Branch, Attn: Marcia Park, 3900 NCTR Road, HFT-322, Jefferson, AR 72079-9502; Faxed to 870/543-7990 or emailed to Marcia.park@fda.hhs.gov. All parties are encouraged to respond to this notice by the above due date with questions and/or comments regarding the specifications identified above.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/FDA/NCTR/Confocal1113350/listing.html)
- Place of Performance
- Address: 29 Lincoln Drive, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02949736-W 20121216/121214234811-8ab933276ec5d5dddd60c3d31d742f05 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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