SOLICITATION NOTICE
66 -- Multi C Components HPLC
- Notice Date
- 8/16/2012
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334519
— Other Measuring and Controlling Device Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, Maryland, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- NICHD-12-084
- Archive Date
- 9/10/2012
- Point of Contact
- Tina Robinson, Phone: 301-443-7796
- E-Mail Address
-
tr207f@nih.gov
(tr207f@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NICHD-12-084 and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-60. The North American Industry Classification (NAICS) Code is 334519 and the business size standard is 500 employees. However, this solicitation is not set aside for small business. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) intend to procure on a sole source basis with Shimadzu Scientific Instruments - 7102 Riverwood Drive - Columba, MD 21046 two separate HPLC systems. The following products/items (with descriptions) are necessary for the configuration/operation of a Multi C Components HPLC and a separate Fluorescent Detector HPLC Multi Component system: 1. P/N: 220-91398-20: CBM-20A W/NETWORK SWITCH - QUANTITY (2) EA CBM-20A w/Ethernet Switch, Central communication and control module for the Prominence Series. System component via fiber optic cables for easy "plug and play" configuration. Internal web server offers convenient control and monitoring of the HPLC system through a web browser. Connector via Ethernet and RS-232C possible; Offers 8 Fiber Optic ports; 4 Events; 2 PC-55N A/D boards can be installed. Includes 4 port 10/100 Ethernet switch. VP and 10A Series modules w/a fiber optic port can be controlled by the CBM-20A. 2. P/N: 220-91405-25: LC-20AT QUATERNARY SOLVENT DELIVERY UNIT QUANTITY (1) EA LC-20AT pump with the Prominence LPGE valve unit installed for solvent selection or quaternary gradient formation. Utilizes serial design dual pistons for routine HPLC analysis at elevated flow rates up to 10 mL/min. Rinse kit for washing the plunger and seal is installed. Flow rates from 0.001 to 10mL/min; 3nL/step resolution; 47µL primary and 24µL secondary pump strokes with sapphire pistons; CBM-20A Lite can be installed; Graphite/Teflon® seals. 3. P/N: 228-45019-43: DGU-20A5R FIVE CHANNEL VACUUM DEGASSER - QUANTITY (1) EA Inline membrane degasser utilizing Teflon AF® for rapid degassing of HPLC mobile phases. Convenient 5th channel for degassing the autosampler rinse phase for optimum injection reproducibility performance. Maximum flow rate is 10mL/min per channel. 4. P/N: 220-91397-02: SIL-20AC UFLC AUTOSAMPLER W/INSTALLATION KIT - QUANTITY (2) EA High speed temperature controlled (4-40C), low carryover autosampler for analytical HPLC. Accommodates several vial sizes and titer plate formats for fast (10 sec.), accurate and precise HPLC sample injection. The needle in the flow path design coupled with patented material technology virtually eliminates carryover. SAMPLE CAPACITIES: 175 1 mL; 70 2 ml; 50 4 mL, 2 MTP (STD 96, DW 96 or STD 384); Control Rack accommodates 10 2mL vials; 0.1 to 100 µL inj vol; 6 nL/step metering pump motor resolution; 2nd Peltier unit for dehumidifying sample compartment. Includes 1.5mL vial rack, 100 1.5mL vials, Promenence vial sample pack and 4.6 x 50mm C18 column and 4-component test mix. 5. P/N: 228-45005-32: SPD-M20A PHOTODIODE ARRAY DETECTOR - QUANTITY (1) EA Variable slit width photodiode array detector with D2 and W lamps for a wavelength range of 190-800nm. The standard temperature controlled flow cell coupled with new noise reduction and optical processing technologies result in extremely low noise and a greatly extended linear range. Includes standard temperature controlled flow cell (9-50C Settable-Minimum is Ambient+5C); 1 cm path length; 10 µL volume; linear to 2.0 AU; D2 and W lamps can be lit simultaneously; 1,2 & 8 nm slit widths; slit switching possible. 6. P/N: 220-91212-71: FRC KIT WITH RACK 1 AND 4.5mL GLASS TUBES -QUANTITY (2) EA Fraction Collector Kit w/Rack 1 and 4.5mL Tubes, includes FRC-10A fraction collector, fraction head w/valve, Rack 1 (144 tube capacity) and 4.5mL glass tubes (pack of 350) 7. P/N: 228-32211-03: RH-77251 ANALYTICAL MANUAL INJECTOR with 1/4" WRENCH - QUANTITY (1) EA Fixed-loop manual injector includes a 20µL sample loop and 1/4" wrench for ease of changing loops and connecting inlet and outlet tubing. Self-contained position sensing switch provides a signal synchronized with the injection to automatically start the CBM-20A, CMB lite and SCL-10Avp controllers or any other date processor. Install on the front panel of any CTO column oven or add the injector mounting plate 228-35659-91 to attach the injector to the side of a pump 8. P/N: 228-35655-91: INJECTOR MOOUNT (MANUAL INJECTOR/COLUMN HOLDER) LC10/10AVP SERIES - QUANTITY (1) EA Pole-type mount holds both a manual sample injector and a column of up to 12.7mm outer diameter and up to 500mm length. Mounts on the side of any LC pump. 9. P/N: 228-32211-16: 100 UL SAMPLE LOOP FOR 7725I MANUAL INJECTOR - QUANTITY (1) EA 100 µL stainless steel sample loop and fittings for the RH-7725i manual injector 10. P/N: 228-32211-18: 500 UL LOOP FOR 7725I MANUAL INJECTOR -QUANTITY (1) EA 500µl stainless steel sample loop and fittings for the RH-7725i manual injector 11. P/N:228-32211-20: 2 ML LOOP FOR 7725I MANUAL INJETOR - QUANTITY (1) EA 2 mL stainless steel sample loop and fittings for the RH-7725i manual injector 12. P/N: 220-91449-10: LCsolution Single-PDA - QUANTITY (1) EA LCSOLUITON SOFTWARE, Single HPLC System with PDA Detector. Shimadzu LCsolution® HPLC Workstation Software to provide system control, data acquisition and reporting for one HPLC System with PDA Detector. Full-function, user-friendly workstation software for Shimadzu HPLC, designed to run in Windows 2000 Pro, Windows XP Professional (SP2/SP3) or Windows Vista Business. This package can control a single Shimadzu HPLC system from a personal computer and perform data acquisition, LC analysis report creation and data management. The software can be optionally scaled up to 4 instruments with up to 4 detectors each. LCsolution supports a networked environment and is equipped with GLP/GMP support and system management functions. With optional CLASS Agent, software includes built-in electronic record and signature functions that comply with the requirements of US FDA's 21 CFR Part 11. LCsolutiion support digital data acquisition through RS-232 or Ethernet connection through the SCL-10avp system controller or the Prominence-series CBM-20A system controller. 13. P/N: 220-97318-10: STANDARD WORKSTATION PC (DELL T3500-W3503)- QUANTITY (2) EA Shimadzu Standard Workstation Mini tower PC w/Inter® Core 2 Duo TM processor (2.40GHz/13337MHz/4MB L2 cache). Operating systems include Windows® 7 Pro 32 bit License (installed). System incorporates 2GB Dual-Channel DDR3 1333MHz SDRAM memory (expandable to 8GB), 250GB SATA hard drive, 16X DVD+/-RW Drive. Includes: USB keyboard, Optical wheel mouse, 512MB PCIe x 16 NVidia Graphics Card, Intel Integrated Gigabit 10/100/1000 network connection, two PCI slots, two x16 PCI Express Slots, one PCI-Express x1, one serial port (R5-232), one Parallel Port, 11 USB 2.0 ports (2 front, 6 back & 3 internal), Integrated High Definition Audio 14. P/N: 220-97320-10: DELL P2210, 22 INCH PROFESSIOAN WIDESCREEN, FLAT PANEL - QUANTITY (2) EA 22" LCD display resolution to 1680X 1050, contrast ratio (typical): 1000:1. Brightness (typical): 300 cd/m2, 0.282 mm pixel pitch 15. P/N: 220-91564-00: HPLC COLUMN W/CONSULTATION - QUANTITY (2) EA Consultation to be provided by Phenomenex about specific column application, etc. for each of the HPLC systems. 16. P/N: 228-45003-32: SPD-20A UV VIS DETECTOR - QUANTITY (1) EA Dual wavelength UV-VIS detector with a wavelength range of 190-700 nm. The standard temperature controlled flow cell coupled with new noise reduction and optical processing technologies result in extremely low noise and a greatly extended linear range. Includes standard temperature controlled flow cell (9-50C Settable-Minimum is Ambient +5C); 1 cm path length; 12 µL volume/ linear to 2.5 AU 17. P/N: 220-91426-04: LC-20AB SPECIAL - QUANTITY (1) EA 18. P/N: 220-91449-05: LCsolution SINGLE-LC - QUANTITY (1) EA LCSOLUTION SOFTWARE, SINGLE HPLC SYSTEM, NO PDA DETECTOR Shimadzu LCsolution® HPLC Workstation Software to provide system control, data acquisition and reporting for one HPLC System with up to 4 detectors. Full-function, user-friendly workstation software for Shimadzu HPLC, designed to run in Windows 2000 Pro, Windows XP Professional (SP2/SP3) or Windows Vista Business. This package can control a single Shimadzu HPLC system from a personal computer and perform data acquisition, LC analysis report creation and data management. The software can be optionally scaled up to 4 instruments with up to 4 detectors each. Each PC can operate with up to 2 PDA detectors, one PDA detector per instrument. LCsolution supports a networked environment and is equipped with GLP/GMP support and system management functions. With optional CLASS Agent, software includes built-in electronic record and signature functions that comply with the requirements of US FDA's 21 CFR Part 11. LCsolution support digital data acquisition through RS-232 or Ethernet connection through the SCL-10Avp system controller or the Prominence-series CBM-20A system controller. 19. P/N: 228-45148-42: RF-20AXS FLUORESCENCE DETECTOR - QUANTITY (1) EA High sensitivity fluorescence detector for HPLC. Features a S/N ration of 2000 for the Raman water peak with fast response and sampling (100 Hz, 10 ms) for UFLC applications including food, pharma and environmental. Temperature controlled flow cell provides excellent area %RSD since fluorescence is quenched at elevated temperatures. Cell cooling from ambient to 10C below ambient allows adequate cooling without condensation. Convenient lamp and cell installation from the front panel requires no positional adjustment. Wavelength range of EX 200-750 and EM 200-750 with optional PMTs for EM measurement to 900 nm. Dual wavelength measurement is possible. 20. P/N: 220-91057-00: VALCO 7-PORT MANIFOLD ANALYTICAL - QUANTITY (1) EA 7-port, 6-position manifold for HPLC column switching. Serves as an alternative to a second FCV-14AH or FCV-20AH6 for multi-column applications 21. P/N: 220-91200-00: LC-20AB CONVERGENCE BLOCK + MIXER - QUANTITY (1) EA Replacement convergence block for the LC-20AB that incorporates a 100 µL mixer. The integrated design reduces the pump's internal volume and eliminates the need for an additional mixer for flow rates up to 10mL/min. 22. P/N: 228-16006-00: PLUG, LC-6A/6AD - QUANTITY (1) EA Stainless steel plug for unused mixer or Valco manifold ports. Can also be used as a column plug 23. P/N: 228-45018-43: DGU-20A3R - QUANTITY (1) EA Inline membrane degasser utilizing Teflon AF® for rapid degassing of HPLC mobile phases. Convenient 3rd channel for degassing the autosampler rinse phase for optimum injection reproducibility performance. 24. P/N: 220-91413-02: 1L BOTTLE/CAP/RES TRAY PKG - QUANTITY (1) EA I-L Solvent Bottles and Caps, plus LC-20 Reservoir Tray. Prominence LC-20A reservoir tray with a set of (5) 1-L solvent bottles and (5) 3-hole caps. Caps include a solid plug and a filter plug with a stainless steel frit. Filter plug included with caps for use with He sparge. 25. P/N: 228-18803-92: SEAL WASHING KIT ASSY, LC-10ADVP, LC-20AB - QUANTITY (1) EA Pump seal wash kit including PE tubing, check vales, 4 unions, base plate and glass flask 26. INSTALLATION AND CUSTOMER FAMILIARIZATION FOR BOTH HPLC SYSTEMS 27. ONE YEAR WARRANTY FOR BOTH HPLC SYSTEMS 28. EXTENDED WARRANY SERVICE FOR THE FLUORESCENT DETECTOR HPLC MULTI COMPONENT SYSTEM. The lab requires a Multi C Components HPLC system at their Rockville, MD location) for analytical to semi-preparative scale work on peptides. Part of the work in the lab will be focused on peptidic toxins that inhibit ion-channels. These toxins are medium sized peptides that have to be isolated from natural sources or have to be synthesized and purified using peptides synthesis. Therefore for both these operations, regular access to an HPLC system w/a UV detector, auto sampler, a fraction collector and that is also capable of flow rates up to 8-10 ml./min. is required. The Shimadzu HPLC system meets the lab needs above as well as it can be reliably used from analytical purposed (flow rates ᷉1 ml. /min.), till all the way to semi-preparative purposes (5 ml. /min.). The HPLC has a Photodiode Array based detector that allows the spectrum to be recorded at each time point along an experiment. The lab also requires a separate Fluorescent Detector HPLC Multi Component system with a fluorescence detector for screening constructs of membrane proteins. In order to crystallize membrane proteins, it is essential to work with a construct that is well-behaved biochemically. The criterion that is usually used for judging this is the behavior on size-exclusion chromatography. A technique that facilitates this process is constructing fusions of candidate constructs with a naturally fluorescent protein. Working with a liquid chromatography system with a fluorescent detector enables tracking of the size-exclusion chromatographic behavior starting from very small amounts of cells that are used for heterologous overexpression of the proteins. This saves time and cost to do large scale overexpression and purification of all possible constructs. This is a very effective way of streamlining time and cost in membrane protein crystallography. The lab has extensive experience in successfully using the system from Shimadzu. Also both the Multi C HPLC and the Fluorescent Detector HPLC system use of the same software interface will make the ease of operation for the combined use of both the systems much better for the lab. These particular configurations for the systems are only offered through Shimadzu directly. The proposed contract action is for supplies or services for which the Government intends to solicit and negotiate with only one source under authority of the 41 U.S.C. 253(c) (1), FAR 6.302. This notice of intent is not a request for competitive quotations however, all responses received, within twelve (12) days from the date of publication of this synopsis will be considered by the Government. The offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-1 Instructions to Offerors - Commercial Items; FAR Clause 52.212-2, Evaluation - Commercial Items; FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items; and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - Deviation for Simplified Acquisitions applies to this acquisition. The offeror must include their Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. The clauses are available in full text at http://www.acquisition.gov/far. Interested vendors capable of furnishing the government with the service specified in this synopsis should submit one (1) copy of their quotation to the below address or via email to robinsti@mail.nih.gov by the due date and time below. Offers must also be accompanied by descriptive literature, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. Quotations will be due twelve (12) calendar days from the publication date of this synopsis or by August 27, 2012 before 10:00 a.m. EST. The quotation must reference "Solicitation number" NICHD-12-084. All responsible sources may submit a quotation, which if timely received, shall be considered by the agency. Quotations must be submitted in writing to Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 5Z00, Bethesda, MD 20852. Attention: Tina Robinson. Any questions must be sent via email to robinsti@mail.nih.gov and must include solicitation# NICHD-12-084 in the subject line of email. Faxed copies/responses will not be accepted. Note: In order to receive an award, contractor must be registered and have valid certification in the Central Contractor Registration (CCR) http://www.ccr.gov.
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