SOLICITATION NOTICE
R -- In vivo analysis of astrocyte dynamics in response to cocaine
- Notice Date
- 7/6/2012
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- NOI2607715
- Archive Date
- 7/31/2012
- Point of Contact
- Hunter A. Tjugum, Phone: 3014358780
- E-Mail Address
-
hunter.tjugum@nih.gov
(hunter.tjugum@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a notice of intent, not a request for a proposal. A solicitation document will not be issued and proposals will not be requested. National Institute on Drug Abuse (NIDA), Office of Acquisitions - Neurosciences, Station Support/Simplified Acquisitions, on behalf of the National Institute on Drug Abuse (NIDA) intends to negotiate and award a purchase order on a noncompetitive basis to the Johns Hopkins Health System Corporation, located at 600 N Wolfe St, Baltimore, MD 21287, for conducting a project under the NIDA Scientific Director's Innovators Partnership Program, a novel and innovative pilot project undertaken by NIDA IRP investigators and extramural research collaborators. The Multiphoton Imaging Core at the Johns Hopkins School of Medicine has developed novel transgenic mice that express a genetically encoded calcium indicator, GCaMP3, selectively in astrocytes of mice. Dwight Bergles, Ph.D., Director, Multiphoton Imaging Core, has developed the mice with this unique trait and is the only source that currently possesses them or has access to them. Detecting chemical changes, selectively expressed in astrocytes in mice via new genetically encoded indicators, can potentially enhance knowledge about physiological and pathological significance of astrocytes signaling. Astrocytes express receptors in most, if not all, neurotransmitters, by influencing neuronal activity by releasing neuroactive substances. Yet, their participation in drug induced changes in neural circuits is unknown. This project will investigate the role that astrocytes have in modulating neuronal responses to psychostimulants, such as cocaine. Research of exposure to psychostimulants suggests that recidivistic behaviors may arise from inappropriate modulation of pathways that enable normal learning. Understanding the many sequelae induced by psychostimulant exposure, and identification of new therapeutic targets for suppressing compulsive behaviors, remain central goals of addiction research. The Multiphoton Imaging Core at the Johns Hopkins School of Medicine is the only known responsible source able to provide access to these services; no other known source can satisfy agency requirements. This acquisition is being conducted under Simplified Acquisition Procedures using FAR 12 procedures, and is exempt from competition requirements in FAR Part 6. The determination by the Government not to compete the proposed contract based upon responses to this notice is solely within the discretion of the Government. Comments to this announcement, referencing the solicitation number, may be submitted prior to the closing date of this announcement to the NIDA SS/SA Branch electronically to the attention of Hunter A. Tjugum at hunter.tjugum@nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/NOI2607715/listing.html)
- Place of Performance
- Address: 251 Bayview Blvd., Baltimore, Maryland, 21224, United States
- Zip Code: 21224
- Zip Code: 21224
- Record
- SN02795731-W 20120708/120706234422-a7e552575f93042c15b6c3be10367171 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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