SOLICITATION NOTICE
66 -- GE Diamond DNP Polarizer
- Notice Date
- 6/15/2012
- Notice Type
- Presolicitation
- NAICS
- 334517
— Irradiation Apparatus Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- N02RC26004-45
- Archive Date
- 7/14/2012
- Point of Contact
- Miguel Diaz, Phone: (301) 402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
miguel.diaz@nih.gov, cr214i@nih.gov
(miguel.diaz@nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Contracting Office Address Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Boulevard, EPS Suite 600, Room 6079, Rockville, MD 20852, UNITED STATES. Description The National Cancer Institute (NCI), Center for Cancer Research (CCR), Radiation Biology Branch (RBB) plans to procure on a sole source basis with General Electric Company, 3000 N Grandview Blvd W-443 Waukesha, WI 53188-1615, for the brand name "GE Diamond SpinLab Dynamic Nuclear Polarizer (DNP)." This acquisition will be processed under FAR Part 12 - Acquisition for Commercial Items and will be made pursuant to the authority in FAR 15, Contracting by Negotiation. The North American Industry Classification System Code is 334517 and the business size standard in 500 employees. This will be awarded as a firm fixed price type contract. It has been determined that there is no opportunity to acquire green products or services under this procurement. 13C based MRI, unlike 1H based MRI (conventional MRI) has 4-5 orders in magnitude lower sensitivity. The ability of 13C MRI in distinguishing various endogenous molecules and metabolic products is much higher than 1H MRI because of the chemical shift differences in their spectra. It is now possible to gain the desired sensitivity using the technique of hyperpolarization which has launched a new branch of MRI called metabolic MRI. The purpose is to obtain a polarizer which can prepare clinical grade 13C labeled tracers such as pyruvate which have the 13C nuclear spin states polarized 4-5 orders in magnitude higher than at equilibrium conditions using a paramagnetic material which is co-frozen with the tracer and dissolved in buffer to conduct human clinical trials. The polarization should take place at temperatures ~1 K to realize the desired extent of polarization. A key requirement is that after 30 minutes for polarization, the material should be dissolved in the dissolution buffer, the paramagnetic material extracted, and the injectate checked for temperature and pH prior to injection into a human subject. The polarizer should be placed in very close proximity to a clinical MRI scanner. The polarizer should be able to achieve >20% polarization of the nuclear spin states of 13C nucleus in endogenous molecules such as pyruvate, fumarate, succinate enriched with 13C. The chemical shift dispersion of 13C which is significantly higher than 1H nucleus will enable to monitor the distribution of the injected tracer and also the breakdown products of the tracer into various metabolites based on 13C chemical shift MRI. This will confer the ability to profile tissues metabolically. Since malignancies and premalignant tissue display metabolic differences, the use of hyperpolarized tracers will confer the ability to non-invasively and serially monitor high-risk groups of people as surveillance for early detection of cancer and intervention. Salient Characteristics of the GE Diamond SpinLab DNP include: (1) A superconducting magnet at 3.5 T, (2) a W-band (95 GHz) EPR irradiation cavity, (3) a cryopump to cool the sample to below 1 K, (4) a helium recovery line to minimize the helium burn off, (5) a system to monitor polarization build up, (6) a quality control module to check pH and temperature before injection, and (7) a sterile fluid path for the injectate to ensure that it is pyrogen free. The Diamond SpinLab DNP is the only known polarizer suitable for clinical use since it utilizes a proprietary dissolution technology which can take a polarized tracer in a pellet at 1K temperature and dissolve it with the buffer solution to bring it to room temperature (300 K) and physiological pH in under 10 seconds after quality control check for pH and removal of EPA. General Electric Company is the manufacturer and only known distributor of the GE Diamond SpinLab DNP and therefore the sole known source. This is not a solicitation for competitive proposals. However, if any interested party believes they can meet the above requirement, they may submit a statement of capabilities. All information furnished must be in writing and must contain sufficient detail to allow the NCI to determine if it can meet the above unique specifications described herein. An original and one copy of the capability statement must be received in the NCI Office of Acquisitions on or before 11:00 AM EST on June 29, 2012. No electronic capability statements will be accepted (i.e. email or fax). An original and one copy must be sent to the NCI Office of Acquisitions at the address stated above. All questions must be in writing and can be faxed (301) 402-4513 or emailed to Miguel Diaz, Contract Specialist, at miguel.diaz@mail.nih.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must have valid registration and certification in the Central Contractor Registration (CCR) www.ccr.gov and the Online Representations and Certifications Applications (ORCA), http://orca.bpn.gov. No collect calls will be accepted. Please reference solicitation number N02RC26004-45 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02RC26004-45/listing.html)
- Record
- SN02777583-W 20120617/120615235312-a87c06ebf624ec813a503b26c4e0ed00 (fbodaily.com)
- Source
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