SOLICITATION NOTICE
B -- Chronic Inflammatory Disease Project
- Notice Date
- 5/18/2012
- Notice Type
- Presolicitation
- NAICS
- 611310
— Colleges, Universities, and Professional Schools
- Contracting Office
- Department of Health and Human Services, Centers for Disease Control and Prevention, Acquisition and Assistance Field Branch (Morgantown), 1095 Willowdale Road, Morgantown, West Virginia, 26505
- ZIP Code
- 26505
- Solicitation Number
- 000HCCB-2012-46227
- Archive Date
- 7/1/2012
- Point of Contact
- Rebecca S Mullenax, Phone: 304-285-5880, Kimberly P Groves, Phone: 304-285-5885
- E-Mail Address
-
rmullenax@cdc.gov, kgroves@cdc.gov
(rmullenax@cdc.gov, kgroves@cdc.gov)
- Small Business Set-Aside
- N/A
- Description
- Title: Chronic Inflammatory Disease Project NOTICE OF INTENT TO ISSUE A PURCHASE ORDER. The Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory Division (HELD), Toxicology and Molecular Biology Branch, 1095 Willowdale Road, Morgantown, WV 26505, hereby announces its intent to issue a purchase order to the University of Pittsburgh to assist NIOSH research scientist in developing and implementing state-of-the-art genetic data analyses and approaches as part of their research projects. STATEMENT OF WORK I. Background The services contemplated under this contract are considered to be an Other Function as defined by the Office of Federal Procurement Policy in OFPP letter 11-01 and by HHS in Acquisition Policy Memorandum 2012-01. Our projects focus on immune-mediated and chronic inflammatory diseases including occupational asthma, chronic beryllium disease and irritant contact dermatitis and investigate genotypes, haplotypes and interactions important in the development, progression and severity of such diseases. These studies will also assess gene-gene and gene-environment interactions. CDC's mission is to promote health and quality of life by preventing and controlling disease, injury, and disability. CDC seeks to accomplish its mission by working with partners throughout the nation and world to monitor health, detect and investigate health problems, conduct research to enhance prevention, develop and advocate sound public health projects, implement prevention strategies, promote healthy behaviors, foster safe and healthful environments, and provide leadership and training. II. Project Objectives Genetic data is generated by high-density and high-throughput genotyping platforms (5' nuclease real-time PCR, microarray technology-Illumina GoldenGate genotyping assays). The genetic variations in MHC region are investigated using SNP microarray platform from Illumina®. The MHC panel set of Illumina® consists of two arrays (2,360 loci) with 2kb average spacing of the MHC locus. The majority of markers are in strong linkage disequilibrium(LD) to at least one other marker. Strong intergenic LD would complicate the assignment of single association signals to particular MHC genes. Therefore, the LD pattern in this region need to be characterized by using a dense map of SNPs and define haplotypes blocks. The custom panel consists of ~1,536 variants that are known to be involved in disease process. Using these platforms, we will examine the influence of genetic variations in selected genes (immune/inflammatory, antioxidant genes and other genes of interest) in the development and outcomes of occupational diseases. The analyses will also include the assessment of gene-gene and gene-environment interactions. III. Scope of Work The contractor will assist NIOSH research scientist in developing and implementing state-of-the-art genetic data analyses and approaches as part of their research projects. This includes to direct the genetic data analyses and produce the summary results of data analyses, along with the formulation of the biological hypotheses tested in the data analyses, in consultation with the NIOSH investigator. Contractor will analyze raw microarray data, create novel computational approaches and analytical tools as required by research goals, develop new applications or customize existing applications to meet specific scientific project needs and produce the summary results of computations. Meetings will be arranged at regular intervals to discuss the progressions in data analyses. Contractor will also assist NIOSH investigator to prepare the scientific reports of data analyses for possible peer-reviewed publications. Oversight and overall direction of the contractor's work will be provided by the NIOSH Project Officer. The contractor will interact with, collaborate with, and respond to feedback and technical direction from the Project Officer as appropriate to the objectives of the project and the scope of work herein detailed. Establishing the nature and extent of such interactions will be the responsibility of the contractor in consultation with the Project Officer, and will be in accordance with government contract procedures. Responsible sources that believe they possess the expertise and capabilities identified above are encouraged to submit to the Contracting Officer within 15 days from the posting date of this notice, their written capabilities statement and pricing information in the format they choose, not to exceed 10 pages. Please forward the capability statement and pricing information to Rebecca Mullenax, Purchasing Agent, Reference 000HCCCB-2012-46227, Centers for Disease Control, NIOSH, ATTN: Rebecca Mullenax, MS: GD, 1095 Willowdale Road, Morgantown, WV 26505. All vendors must be registered in the Central Contractor Registry (CCR) prior to an award of a federal contract. The website is: www.ccr.gov. The Government will review any/all capabilities statements and pricing information submitted and determine if other qualified sources do exist that could provide this requirement. Information received in response to this announcement will be used solely for the purpose of determining whether to conduct a competitive procurement. If no affirmative responses are received within 15 days, in accordance with FAR 13.106-1(b)(1), negotiations will be conducted with The University of Pittsburgh, 3520 Fifth Avenue, Pittsburgh, PA 15213-3320, as the only source and a purchase order will be issued without any additional notices being posted.
- Web Link
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FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/CDCP/MNIOSH/000HCCB-2012-46227/listing.html)
- Record
- SN02752952-W 20120520/120519001118-e9ba9be3c4f10c7a17cb0c1cdb3bbf25 (fbodaily.com)
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