MODIFICATION
66 -- Laboratory Equipment
- Notice Date
- 4/21/2012
- Notice Type
- Modification/Amendment
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, Food and Drug Administration, Office of Acquisitions and Grants Services, 5630 Fishers Lane, Room 2129, Rockville, Maryland, 20857-0001
- ZIP Code
- 20857-0001
- Solicitation Number
- FDA1101882
- Archive Date
- 5/11/2012
- Point of Contact
- David - Kordel,
- E-Mail Address
-
david.kordel@fda.hhs.gov
(david.kordel@fda.hhs.gov)
- Small Business Set-Aside
- Service-Disabled Veteran-Owned Small Business
- Description
- The following Parts have been amended: 3.2.2. All interface apertures preferably should be concentric with the ion axis. These interface specifications have been found to be optimal for the analysis of ciguatoxins in fish. 3.3.1. The mass analyzer preferably should be a high performance linear triple quadrupole-linear ion trap mass analyzer with a high performance collision cell and a linear ion trap or equivalent to achieve the specifications below, which have been found to be optimal for the analysis of ciguatoxins in fish. The mass analyzer instrument shall be capable of analyzing ciguatoxin at a sensitivity of 2 fg on column with a S/N > 10. 3.3.2. The mass analyzer preferably should be capable of the following minimum performance specifications: 3.4.1. It preferably should be possible to analyze 1000 MRM transitions in a single 7 minute HPLC analysis without the use of periods. The instrument offered shall automatically optimize the dwell time for each MRM transition in the acquisition. 3.6.1. When infusing 0.20 pmol/µL reserpine solution at a flow rate 10 µL/min and scanning at 1000 amu/sec with Q0 trapping activated, the intensity of the fragment ion at m/z 397 resulting from fragmentation of the parent ion at m/z 609 preferably is greater than 3.0 x 107 cps for 20 scans MCA and exceed 100% of the intensity of the Q1 precursor ion (m/z 609). When infusing 0.20 pmol/µL reserpine solution at a flow rate 10 µL/min and scanning at 4000 amu/sec with Q0 trapping deactivated, the intensity of the fragment ion at m/z 397 resulting from fragmentation of the parent ion at m/z 609 preferably is greater than 3.0 x 106 cps for 20 scans MCA. 3.7.1. When infusing 0.20 picomole/µL of reserpine at 10µL/min, the intensity of the secondary fragment ion m/z 236 (a fragment of the primary fragment ion m/z 397) for a single 1000 amu/sec MS/MS/MS scan preferably will exceed 10% of the intensity of its precursor ion (m/z 397) from the Enhanced Product Ion Scan. 3.9.2. The instrument preferably should possess data compatibility to maintain the continuity of pre-existing data, cross verification and data transferability from an existing AB SCIEX hybrid linear ion trap-triple quadrupole mass spectrometer for the analysis of ciguatoxins in fish.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/FDA/DCASC/FDA1101882/listing.html)
- Record
- SN02728275-W 20120423/120421233023-87607fca1a7a37ead7afb7870b723f3b (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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