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FBO DAILY ISSUE OF JULY 31, 2011 FBO #3536
SOLICITATION NOTICE

A -- Structural Genomics Centers for Infectious Diseases

Notice Date
7/29/2011
 
Notice Type
Presolicitation
 
NAICS
541711 — Research and Development in Biotechnology
 
Contracting Office
Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions, 6700 B Rockledge Room 3214 MSC7612, Bethesda, Maryland, 20892-7612
 
ZIP Code
20892-7612
 
Solicitation Number
NIAID-DMID-NIHAI2011124
 
Point of Contact
James D Carder, Phone: (301) 402-6289, George Kennedy, Phone: 301-451-2607
 
E-Mail Address
jc490y@nih.gov, kennedyg@niaid.nih.gov
(jc490y@nih.gov, kennedyg@niaid.nih.gov)
 
Small Business Set-Aside
N/A
 
Description
SYNOPSIS Introduction The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), of the Department of Health and Human Services (DHHS) supports research related to the basic understanding of microbiology and immunology leading to the development of vaccines, therapeutics, and medical diagnostics for the prevention, treatment, and diagnosis of infectious and immune-mediated diseases. The NIAID, Division of Microbiology and Infectious Diseases, has a requirement for a Structural Genomics Research Program. Description The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is seeking qualified contractors under this Request For Propsoal (RFP) to provide the following: NIAID is recompeting the Structural Genomics Centers for Infectious Diseases program, herein referred to as the SGCID program. This program will build upon the objectives of the NIAID Genomics programs (http://www.niaid.nih.gov/topics/pathogenGenomics/research/Pages/relatedInitiatives.aspx) to continue to address the Institute's need to further expand the knowledge of the proteome of microbes. The NIAID awarded two 5-year contracts in 2007 to support the Structural Genomics Centers for Infectious Diseases 1. SSGCID: Seattle Structural Genomics Center for Infectious Diseases (Contract No. HHSN272200700057C) 2. CSGID: Center for Structural Genomics for Infectious Diseases (Contract No. HHSN272200700058C) To date, the incumbent Centers have utilized high-throughput structural biology technologies and determined more than 550 three-dimensional (3D) structures of protein targets of biomedical interest from bacterial, viral, and eukaryotic pathogens. Both Centers have been utilizing small molecule/ligand screening to increase crystallization success rate and to gain functional insight through the newly observed protein-ligand interactions. The targets' 3D structure information, as well as the expression clones and peptide materials for thousands of protein targets are made rapidly available to the scientific community. Importantly, these Centers have also been providing a 3D structure determination service to the scientific community and approximately 100 3D structures were solved for community targets. The contracts to be awarded under this solicitation will continue to supply the 3D structure information, reagents and services to the broad scientific community. The contracts are expected to apply state-of-the art high-throughput (HTP) technologies and methodologies to experimentally characterize the 3D atomic structure of proteins or other molecules having an important biological role belonging to human pathogens, especially those in the NIAID Category A-C Priority Pathogen lists (http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/research/Pages/CatA.aspx) and organisms causing emerging and re-emerging infectious diseases (http://www.niaid.nih.gov/topics/emerging/Pages/list.aspx). The SGCID program will also allow for support of research projects that utilize experimental approaches to better characterize the molecular functional role of protein targets whose structure was determined by the incumbent and the to be awarded SGCID. The structure determination services to be provided by the SGCID program to the scientific community are expected to encourage the establishment of collaborations of the SGCID centers with outside investigators that will make use of the provided 3D structure information and of other resources to gain further knowledge about the targets' functional mechanisms. The molecular 3D structure may also assist drug design and development by yielding direct insights into the target molecular mechanisms, in interaction with other biological molecules, or with synthetic compounds, in order to improve selectivity, specificity and optimize drug development in a rational way. This RFP is anticipated to result in multiple awards to offeror(s) capable of performing all aspects Statement of Work. The anticipated contract award(s) are expected to be cost-reimbursement, level of effort type contracts. This requirement will consist of one (1) base period of one (1) year and four (4) one (1) year option periods. In addition to the base level of effort, each year of performance is anticipated to contain an option for up to 3 additional FTEs, in the postdoctoral, technical, and other professional staff. All responsible and qualified sources may submit a proposal which shall be considered by the Government. This advertisement does not commit the Government to award a contract. The North American Industry Classification System (NAICS) code for this project is 541711 with a size standard of 500 Employees. The RFP is scheduled for electronic release via the FedBizOpps.gov https://www.fbo.gov/ on or about August 15, 2011 and receipt for proposals will be due on or about 2:30 p.m., Eastern Prevailing Time on November 7, 2011. Interested parties are expected to review this notice and the Request for Proposal to familiarize themselves with the requirements of the project; failure to do so will be at your firm's own risk. All information required for submission of a proposal will be contained in the electronic RFP package. Only electronic copies of the RFP will be available. It is the offeror's responsibility to monitor the above internet site for the release of this RFP and any amendments. POTENTIAL OFFERORS WILL BE RESPONSIBLE FOR DOWNLOADING THEIR OWN COPY OF THE REQUEST FOR PROPOSAL AND AMENDMENTS. No collect calls will be accepted.
 
Web Link
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIAID/NIAID-DMID-NIHAI2011124/listing.html)
 
Record
SN02514848-W 20110731/110729234450-6c0a4cf811373ca409ab453a4f0c427d (fbodaily.com)
 
Source
FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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