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FBO DAILY ISSUE OF JULY 22, 2011 FBO #3527
SOLICITATION NOTICE

66 -- Multimode Plate Reader - Brand Name or Equal

Notice Date
7/20/2011
 
Notice Type
Combined Synopsis/Solicitation
 
NAICS
334516 — Analytical Laboratory Instrument Manufacturing
 
Contracting Office
Department of Health and Human Services, Food and Drug Administration, Office of Acquisitions and Grants Services, 5630 Fishers Lane, Room 2129, Rockville, Maryland, 20857-0001
 
ZIP Code
20857-0001
 
Solicitation Number
FDA-SOL-1088510A
 
Archive Date
8/9/2011
 
Point of Contact
Natalie Mitchell, Phone: 3018279606
 
E-Mail Address
natalie.mitchell@fda.hhs.gov
(natalie.mitchell@fda.hhs.gov)
 
Small Business Set-Aside
N/A
 
Description
Statement of Work (SOW) Multimode plate reader Part I: General Information A. Introduction Procurement of multifunctional plate reader for quantitative analysis of functional antibodies and protein:protein interactions B. Background Presently we rely heavily on the use of an older model plate reader Victor X. This plate reader is used on a daily basis by our lab as well as others to generate data critical to our mission within the Division of Viral Products. At this point the Victor X has become dated and we require an update to this instrument to keep up with changing technologies. Influenza virus is a major human pathogen that causes morbidity and mortality each year in the United States. The Division of Viral Products at CBER has traditionally facilitated the manufacture of seasonal flu vaccines. With the pandemic threats there is also a need for CBER to support pandemic vaccine production. Technology to accurately quantify protein interactions (antibody/antigen) and binding avidity is an essential tool to evaluate immune responses to vaccines. A range of technologies are used, depending on the level of sensitivity needed, the substrates at hand, and validated protocols. We currently use photometry to measure antibody responses to antigens, fluorometry and luminescence to measure neuraminidase activity of influenza and will need to use a label-free method to determine binding avidity of virus to cells or antibodies to antigen. C. Scope Our objective is to obtain a multimode plate reader capable of measuring the following outputs: absorbance, fluorescence, luminescence, label-free interactions with cells, label-free protein:protein (biochemical) interactions. The plate-reader will be used for important regulatory-based research projects. Part II: Work Requirements A. Technical Requirements 1. Benchtop instrument with multiple read-out technologies, to include photometry, luminometry, fluorometry, as well as label-free technology 2. Must have plate stacking capabilities (at least 20 plates per stack) 3. Must have at least 2 automatic injectors 4. The label-free technology should have capacity to perform cell-based assays as well as measure biochemical interactions 5. The instrument must have integrated full scale computer with software including IC50/EC50, linreg, spline, 4PL/5PL curve fitting capabilities, concentration calculations, flexible report formatting and automatic data export; Full size touch screen software interface is beneficial 6. The instrument must be capable of reading either 96-well or 384 well plate formats 7. Will be advantageous to include Alpha Technology capability with optimized laser excitation and plate cooling feature to ensure maximum sensitivity (<100 amol) and throughput, as well as pre-programmed and validated AlphaLISA assay protocols 8. Should have high performance quad monochromator with 5nm bandwidth on both excitation and emission for maximum precision. 9. The instrument must include injectors 2. Installation and Training • Components should be installed to meet specifications as written in bid response and must be met after any service visits • On-site training should be complete within 6 weeks of instrument delivery 3. Warranty • Shall include 1 year extended warranty or base (one year from date of delivery/installation) for all components and software. • Shall include 4 additional years extended warranty or base (after the initial year warranty) for all components and software listed as follows: Option 1 Option 2 Option 3 Option 4 B. Deliverables Contractor shall deliver and install to specifications, set up analytical software and provide warranty and training in instrumentation and analysis. Part III: Supporting Information A. Security Contractor shall pass through NIH Main Campus (Bethesda) security for access to NIH Campus and deliver to 29 Lincoln Drive, Building 29A loading dock, Bethesda, MD 20892 B. Place of Performance Deliver to: Attn: Katie Harris 29 Lincoln Drive Bldg. 29A Rm. 1D24 (via loading dock) Bethesda, MD 20892 301-402-3846 C. Period of Performance Delivery shall occur 30-60 days from date of award. Part IV: Evaluation Criteria • Meets all technical performance requirements • Price/ Best Value
 
Web Link
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/FDA/DCASC/FDA-SOL-1088510A/listing.html)
 
Place of Performance
Address: 29 Lincoln Drive, Bldg. 29A Room 1D24 (Loading Dock), Bethesda, Maryland, 20892, United States
Zip Code: 20892
 
Record
SN02504407-W 20110722/110721002005-30cd926b4705865d64cadcdacedc2895 (fbodaily.com)
 
Source
FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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