SOLICITATION NOTICE
A -- Research in Prevention and Treatment of Noise-Induced Hearing Loss (NIHL) - Full Announcement
- Notice Date
- 3/17/2011
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of the Navy, Office of Naval Research, ONR, CODE ONR-02, 875 North Randolph St., Suite 1425, Arlington, Virginia, 22203-1995
- ZIP Code
- 22203-1995
- Solicitation Number
- ONRBAA11-018
- Archive Date
- 7/18/2011
- Point of Contact
- Patrick Sisk, Phone: 703-696-6804, Kurt Yankaskas,
- E-Mail Address
-
Patrick.Sisk@navy.mil, kurt.yankaskas@navy.mil
(Patrick.Sisk@navy.mil, kurt.yankaskas@navy.mil)
- Small Business Set-Aside
- N/A
- Description
- Full Announcement posted 17 MAR 2011. The Office of Naval Research, Warfighter Protection and Applications Division of the Warfighter Performance Department (Code 342) is soliciting white papers (preproposals) and proposals in the following topic areas within the NIHL Program. Noise-induced hearing loss (NIHL) and tinnitus are currently the largest areas of disability compensation by the Veterans Administration (VA) and both greatly affect our service members. Hearing deficits have a deleterious impact on operational readiness and service member quality of life. The field of hearing preservation and restoration covers a broad area of research topics. Research in the following areas is required. 1. Capability to preserve and restore hearing. a. Studies of hair cell regeneration. This may include stimulation of endogenous cells for replacement of lost cells or transplantation of stem and/or progenitor cells. Endogenous stimulation may include genetic, neurotrophic, pharmacologic, or other approaches. Stem cell research may include adult or embryonic stem cells. (Note: If the offeror anticipates that the use of embryonic stem cells may be needed to perform the proposed research, it must provide adequate information to demonstrate compliance [or a plan of compliance] with applicable executive orders, statutes, regulations, and other guidance on use of pluripotent stem cells. This is expected to include information about how the stem cells to be used in the proposed research were derived.) b. Prevention and/or treatment of hair cell loss. This may include pharmacologic approaches, prevention of apoptosis, manipulation of signaling systems, enzyme and/or antioxidant treatment/mimicry, etc., and the development of novel cochlear implant technology. 2. Capability to identify individual/population susceptibility to noise-induced hearing loss/tinnitus a. Studies on genetics/biomarkers. This may include assessing the variations in DNA sequencing to elucidate genotype single nucleotide polymorphisms that are correlated to NIHL and/or tinnitus, studies on inheritable traits as risk factors, or other biomarker/biometric approaches. b. Development and validation of assessment tools. This may include studies on the use of otoacoustic emissions, pre-existing hearing loss, or other reliable methods/factors that can rapidly assess susceptibility. 3. Development of tools and methodologies that rapidly assess changes in hearing thresholds and recommend the most effective individual mitigation/treatment strategies. 4. Advanced training tools for the audiologist and service member that demonstrate hearing loss and tinnitus, and that promote the correct use of hearing protection. 5. Surgical and nonsurgical approaches to the treatment of combat-related middle and inner ear trauma, including reconstruction, replacement, or augmentation of hearing structures. 6. Basic research elucidating the etiology of tinnitus. 7. Development of prototype technologies or specifications for prototype development to monitor/reduce individual noise exposure, either through passive/electronic hearing devices or noise exposure reduction.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/DON/ONR/ONR/ONRBAA11-018/listing.html)
- Record
- SN02403220-W 20110319/110317234450-721cdcf99987da39725fc63ea1384463 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |