SPECIAL NOTICE
Q -- Detection changes in gene expression and their association with patients.
- Notice Date
- 1/10/2011
- Notice Type
- Special Notice
- NAICS
- 621511
— Medical Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, Office of Administration, 6011 Executive Blvd, 5th Floor, Rockville, Maryland, 20852-3804, United States
- ZIP Code
- 20852-3804
- Solicitation Number
- HHS-NIH-OD-OLAO-GZ-11-001
- Archive Date
- 2/8/2011
- Point of Contact
- Doris M Vaughn, Phone: 301-402-3351
- E-Mail Address
-
vaughn@od.nih.gov
(vaughn@od.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- THIS IS A NOTICE OF INTENT, NOT A REQUEST FOR QUOTE. A SOLICITATION DOCUMENT WILL NOT BE ISSUED AND QUOTES WILL NOT BE REQUESTED. The National Institutes of Health (NIH) intends to negotiate and award a purchase order on a noncompetitive basis with Affymetrix. The NINR IRP labs have been using the Affymetrix system to detect the changes in gene expression and their association with patients’ symptoms, such as acute inflammation, acute inflammatory pain, and cancer treatment related complications such as radiation therapy-induced fatigue and chemotherapy-induced peripheral neuropathy. The Affymetrix Genome-Wide Human SNP Array 6.0 is one of the most dense whole genome SNP scanning chips. This product is the latest available and the only compatible whole genome scan with the scanner that already exists in the NINR lab. We already finished more than 1000 samples with this SNP Array 6.0 and the same set of 1,000,000 SNPs and 1,000,000 copy number variations should be applied for the consistency of the data variables. There is no alternative assay to replace the SNP Array 6.0 and reaction kits. The HG U133Plus2.0 and 3’ IVT expression system (Affymetrix, Inc) measure changes in global gene expression from human specimens. We have been using this system to detect the changes in gene expression and their association with patients’ symptoms, such as acute inflammation, acute inflammatory pain, and cancer treatment related complications such as radiation therapy-induced fatigue and chemotherapy-induced peripheral neuropathy. This system allows us to use only 100 ng of input total RNA to analyze the whole human gene expression. This decreased input material is a huge advantage for our purpose as in clinical studies we are always facing the challenge to get enough specimen from patients. NINR IRP laboratories have been facilitated with the Affymetrix system to ensure the outcome reliability without technical bias in data acquisition and assessment. NINR IR continues the use of the Affymetrix system in order to keep studies consistent, and productive. Comments to this notice may be furnished to vaughndl@od.nih.gov.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/OoA/HHS-NIH-OD-OLAO-GZ-11-001/listing.html)
- Place of Performance
- Address: Bethesda, Md, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02357170-W 20110112/110110233849-5898443dc67cba43a9f854676a271e39 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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