SOLICITATION NOTICE
D -- Computational Simulations of Biophysical Processes - Statement of Work
- Notice Date
- 5/21/2010
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541511
— Custom Computer Programming Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Library of Medicine, 6707 Democracy Blvd., Suite 105, Bethesda, Maryland, 20894, United States
- ZIP Code
- 20894
- Solicitation Number
- NLM-10-130-RTR
- Archive Date
- 6/12/2010
- Point of Contact
- Russell T. Reeves, Phone: 3014354381
- E-Mail Address
-
reevesru@mail.nih.gov
(reevesru@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Statement of Work This is a combined synopsis/solicitation for Commercial Items prepared in accordance with the format in Federal Acquisition Regulation (FAR) Subpart 13.5, Test Program for Certain Commercial Items, as supplemented with additional information included in this announcement. This solicitation incorporates provisions and clauses in effect in the March 2005 FAR Revision, including all FAR Circulars issued as of the date of this synopsis. It is the intent of the Center for Information Technology (CIT), National Institutes of Health (NIH), to negotiate on a sole source basis with Leonardo Dagdug, Ph.D., Aldama No. 117 Casa 25, Mexico, Distrito Federal 16020, to acquire professional subject matter expertise in numerical simulation for a 24-month period to assist CIT's Division of Computational Bioscience (DCB) in the analysis of problems of molecular transport through membrane channels. DCB is currently collaborating with the National Institute of Child Health and Human Development (NICHD), NIH, in the analysis of problems of molecular transport through membrane channels. Specifically, NICHD and CIT are planning to develop a comprehensive theory of blocking of membrane channels by small molecular blockers and to use this theory to analyze detailed experimental data on blocking, such as the blocking of the Anthrax Channel by cyclodextrins. These data are reported in a paper recently accepted for publication. [Reference: Nestorovich, E. M. et. al. "Blockage of Anthrax PA63 Pore by a Multi-Charged High-Affinity Toxin Inhibitor." Biophysical Journal]. This ambitious 24-month program will involve computer simulations which will be used to model the blocking with the goal to clarify the picture of the process and to check the accuracy of accepted approximations. In order to support the CIT-NICHD 24-month collaborative project, DCB requires contracted computational expertise in the simulation of complex processes like channel-facilitated membrane transport, endosomal sorting, etc. The contracted subject matter expert must possess an advanced degree in Statistical Physics and an established expertise in the field of numerical simulation of biomedical processes at the molecular level. In addition, the Contractor must possess all of the following: 1. A deep understanding of: a. Physical kinetics and non-equilibrium statistical mechanics, including theory of transport in compartmentalized media that imitate intra-cellular space, and theory of diffusion-limited reactions; b. Biophysics, including theories of membrane transport and the channel- facilitated transport; and c. Theory of random walks and stochastic processes in application to transport problems in biophysics, like transport of macromolecular solutes through large membrane channels and transport of glucose by specialized transporters. 2. Expertise and demonstrable experience in multiple mathematical programming languages, including, Fortran, Mathematica, Matlab, Scilab, or similar. 3. Expertise and demonstrable experience with advanced operating systems including Linux, Unix, and languages including C++. 4. Expertise and demonstrable experience in carrying out scientific computations on large parallel clusters using Unix, LSF, BSF. 5. Expertise and demonstrable experience with numerical simulations of continuous and discrete systems, numerical solution of partial and ordinary differential equations. During previous post-doctoral work at DCB, Dr. Leonardo Dagdug acquired a unique combination of experience and expertise in numerical simulation by directly supporting the CIT-NICHD collaborative project, including the efforts leading to the preparation of the previously mentioned article scheduled to be published. During the past 10 years under his post-doctoral assignment, Dr. Dagdug collaborated with DCB scientific staff in researching problems including transport in conical channels, diffusion-controlled binding to a site located on the wall of a membrane channel, particle equilibration between two cavities connected by a channel, ligand equilibration between tubular and vesicular parts of the endosome in the endosomal sorting, diffusion in tubes with dead ends, and entropy barrier effect on diffusion. As a result of his previous work, he has acquired a unique computational expertise in the simulation of complex processes like channel-facilitated membrane transport, endosomal sorting, etc. This expertise has been crucial to the CIT-NICHD collaborative project which is expected to result in the development of a comprehensive theory of channel blocking by small molecule blockers. Over the past 10 years, Dr. Dagdug, who holds a Ph.D. in Statistical Physics, has collaborated with NIH investigators and jointly published a number of papers on the subject matter with DCB scientific staff who have directly supported the CIT-NICHD collaborative project. CIT has determined that Dr. Dagdug is the only commercially available source with the required combination of previous experience and computational skills who can successfully provide the necessary subject matter expertise to assist CIT-NICHD with the simulation of complex biophysical processes during the CIT-NICHD 24-month collaborative project. This notice of intent is not a Request for Quotations (RFQ), nor is an RFQ available. However, all responsible and responsive sources may submit descriptive literature fully documenting their experience and expertise which will be considered by the agency. Sources interested in responding to this notice must be able to provide convincing evidence that they can fulfill all of the requirements specified above. Information received in a timely manner will be considered solely for the purpose of determining whether to conduct a competitive procurement. A determination by the Government to conduct a competition for this proposed acquisition based upon responses to this notice is solely within the discretion of the Government. This requirement is being processed for CIT by the National Library of Medicine (NLM). NLM intends to make an award for this commercial item in accordance with FAR Subpart 13.5, Test Program for Certain Commercial Items. The following clauses and provisions apply to this acquisition and may be obtained from the web site http://rcb.cancer.gov/rcb-internet/SAP/sap.htm: FAR 52.212-1, Instructions to Offerors; 52.212-3, Offeror's Representations and Certifications; 52.212-4, Contract Terms and Conditions, and FAR 52.212-5, Contract Terms and Conditions Required to Implement Statutes. The Contractor shall comply with all other applicable Federal, state, and local laws, executive orders, rules and regulations in effect at time of award. Full text of FAR clauses and provisions are available at: http://www.arnet.gov/far/index.html. Responses must be received by the NLM Point of Contact within ten (10) calendar days from the publication date of this notice. NLM Synopsis No. 10-130-RTR shall be noted on all correspondence to this announcement. RESPONSES SHALL BE SENT VIA EMAIL TO: Russell Reeves at reevesru@mail.nih.gov. Inquiries regarding this notice may be made to Russell Reeves (301) 496-6546; Fax 301 402-0642.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/OAM/NLM-10-130-RTR/listing.html)
- Place of Performance
- Address: 12 South Drive, Bethesda, Maryland, 20814, United States
- Zip Code: 20814
- Zip Code: 20814
- Record
- SN02157206-W 20100523/100521235651-afbcee380012056c5189bb33ed108fc7 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
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