SOLICITATION NOTICE
66 -- Bioreactor System and accessories
- Notice Date
- 5/13/2010
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 334516
— Analytical Laboratory Instrument Manufacturing
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-PB-(HL)-2010-149-DDC
- Archive Date
- 6/2/2010
- Point of Contact
- Deborah - Coulter, Phone: (301) 435-0368
- E-Mail Address
-
dc143b@nih.gov
(dc143b@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR 12.6 as supplemented with additional information included in this notice. This announcement constitutes the only solicitation and a separate written solicitation will not be issued. This solicitation number is NHLBI-PB-(HL)-2010-149-DDC and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-40 (4//2009). The total contracted dollar amount, including options, if any will not exceed $5 million. The acquisition is being conducted as a full and open competitive, with no set aside restrictions. The North American Classification System (NAICS) code applicable to this requirement is 334516 and the associated small business size standard is 500 employees. The delivery point is the National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, Maryland. The Government=s anticipated delivery date is +/-8 weeks after receipt of purchase order. Market research conducted by the Government in the FedBizOpps for fifteen days, and there were no responses to the Source Sought. The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), Office of Acquisition (OA), intends to award a single, fixed priced purchase order for the specification listed below. Government Specifications for Bioreactor The Molecular Virology and Gene Therapy Laboratory (GDBC/NHLBI/NIH) is seeking a bioreactor system for growing invertebrate cells in volumes ranging from 50 liters to 500 liters. There are two aspects to such a system, 1) the vessel and mechanical components, and 2) the system controller and data recorder. The vessel consists of a support container that accommodates a sterile, single-use liner, often referred to as a bag. The bag is designed for maintaining cells in suspension using a mechanical agitator and provides a means for aseptically introducing the monitoring probes, withdrawing sample, introducing inocula, bottom drain port for harvesting and venting through sterile filters. Either disposable or re-sterilizable probes are acceptable, provided that the probes communicate with the controller system. Temperature regulation is critically important and requires an external circulating chiller with sufficient power to raise the cell culture growth medium from 4oC to 28oC, and maintain that temperature indefinitely. Temperature set points of 37oC and 4oC are necessary as well for processing the material. An additional requirement is that the starting volume is approximately 20 to 25% of the final volume. This allows the cell culture volume to be expanded in the same vessel / bag used for the final culture and production. The minimum working volume, referred to as the “turn-down” ratio, of 1:4 or 1:5 is essential and avoids the use of several feeder bioreactors to generate the material for large volume productions. For example, a 500 liter bioreactor with a 1:2 turn-down requires a minimum working volume of 250 liters whereas a 1:5 turn-down requires a minimum working volume of 100 liters. The working volume range of 50 to 500 liters may be achieved through two vessels with 1:5 turn-down: a 250 liter vessel (working volumes 50 – 250 liters) and a 500 liter vessel (working volumes 100 – 500 liters). The second component of the system regulates the culture conditions and maintains the optimum growth conditions. The parameters that require stringent regulation are: temperature, dissolved oxygen, and agitation. The acidity (or pH) of the culture is monitored, but not regulated. These parameters are regulated through a feedback loop that constantly makes adjustments depending on cell culture demands. For example, cells initially diluted to the final working volume have relatively low demands for oxygen. However, as the cell density increases, the oxygen demand also increases and the system has to respond by adjusting the gas flow and gas mixture (typically a mix of oxygen and air is used). FAR Provisions apply to this acquisition are: FAR Clause 52.212-1 Instructions to Offerors Commercial Items (JUN 2008) 2) As stated in FAR Clause 52.212-2 (a), The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: The purchase order award will be made to the Offeror whose Part meets the Government=s minimum performance specifications, and delivery date. The Offeror must include a completed copy of the provision of FAR Clause 52.212-3, Offeror Representations and Certifications - Commercial Items with its offer. The provisions of FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items, applies to this acquisition. The addendum to FAR Clause 52.212-4, Contract Terms and Conditions - Commercial Items, is as follows: The Offeror must include in its quote, the unit price, the list price, shipping and handling cost, the delivery date, prompt payment discount terms, the F.O.B. point (Destination or Origin), and provide descriptive literature inclusive of specifications as part of the quotation. The DUN and Bradstreet Number (DUNs), the Taxpayer Identification Number (TIN), and the business size. The Offeror must be registered in the Government=s Central Contractor Registry (CCR) System, which is available at www.ccr.gov. NOTE: The Offeror must be registered in the Government=s Central Contractor Registry (CCR) System, which is available at www.ccr.gov, in order to receive an award from the NIH, NHLBI. The FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders - Commercial Items - apply to this acquisition. The clauses are available in full text at http://www.arnet.gov/far. Interested vendors capable of furnishing the government with the item specified in this synopsis should submit their quotation to the below address. Offers are due on May 18, 2010, 7:30 a.m. EST at the National Heart, Lung and Blood Institute, Office of Acquisitions, Procurement Branch, 6701 Rockledge Drive, Room Number 6142, Bethesda, Maryland 20892-7902. The electronic transmission must reference the solicitation number: NHLBI-PB-(HL)-2010-149- DDC. Attention Deborah Coulter, Contract Specialist, (301) 435- 0368. Quotations may be submitted electronically to coulterd@nhlbi.nih.gov. Faxed copies will not be accepted. All responsible sources may submit a quotation/proposal, which if timely received, shall be considered by the agency.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-PB-(HL)-2010-149-DDC/listing.html)
- Place of Performance
- Address: NIH, Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02148915-W 20100515/100513235306-69907599b8755a8159bde857c4cd2443 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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