SOLICITATION NOTICE
R -- Professiona Services
- Notice Date
- 4/5/2010
- Notice Type
- Combined Synopsis/Solicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung and Blood Institute, Rockledge Dr. Bethesda, MD, Office of Acquisitions, 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, Maryland, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- NHLBI-PB-(HG)-2010-125-RSF
- Archive Date
- 4/27/2010
- Point of Contact
- Rashida S. Ferebee, Phone: 3014352605
- E-Mail Address
-
ferebeers@nhlbi.nih.gov
(ferebeers@nhlbi.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR12.6 as supplemented with additional information included in this notice. This notice constitutes the only solicitation and a separate written solicitation will not be issued. The solicitation number is NHLBI-PB-(HG)-2010-125-RSF and is issued as a Request for Quotation (RFQ). The solicitation/contract will include all applicable provisions and clauses in effect through Federal Acquisition Circular 2005-038 (February 1, 2010). The North American Industry Classification (NIACS) Code is 541712, and the business side standard is $10.0 Million. This acquisition is being conducted using Simplified Acquisition Procedures in accordance with FAR Part 13. The National Institutes of Health (NIH) in Bethesda, National Heart, Lung and Blood Institute (NHLBI), Office of Acquisitions (OA) for the National Human Genome Research Institute has a requirement for an experienced genetic statistician. A. BACKGROUND INFORMATION The National Human Genome Research Institute (NHGRI), Division of Intramural Research (DIR), overall mission is to develop and implement technology for the rapid isolation, analysis, and treatment of genetic diseases. The Division=s research laboratories and clinical branches develop and use the most advanced techniques to study the fundamental mechanisms of inherited and acquired genetic disorders. Research also includes planning and conducting clinical trials to test DNA-based methods for treatment and perhaps the cure of such diseases. Researchers collect and study families in which important diseases are inherited, as well as translate basic science advances into effective, reliable, and cost effective DNA and cytogenetic-based diagnostics. This contract covers work to be performed as part of continued collaborative efforts under protocols OH95-HG-N0158, Genetic Analysis of Hereditary Prostate Cancer and 10-CH-0022 Exome Sequencing in Autism Spectrum Disorder. B. PURPOSE AND OBJECTIVE OF THIS PROCUREMENT The purpose of this procurement is to provide professional services to the researchers dedicated to the study. These services will be in the areas of providing statistical genetic analyses for the Finnish Prostate Cancer study, the AAHPC study and the Autism Sequencing study. The successful offeror will work with the Inherited Disease Research Branch of NHGRI to perform linkage and association analyses of prostate cancer in human pedigree data. He/she will be involved in this large collaborative effort to identify, isolate and characterize currently unknown genes for this disease. The Finnish Prostate Cancer study is a major collaboration between investigators at NIH and in Finland who have collected high-risk families for prostate cancer and are looking for evidence of genetic susceptibility loci in the families. The AAHPC study is a major collaboration between investigators at NHGRI, Howard University, Translational Genomics Research Institute, and Fox Chase Cancer Center, with the data collection portion funded by a prior contract between NHGRI and Howard University. The Austism sequencing study is a major collaboration between intramural investigators at NICHD and NHGRI. The contractor will assist with the statistical analyses of the data generated in these studies. C. CONTRACTOR REQUIREMENTS The contractor will engage in several activities, including assisting the Inherited Disease Research Branch of NHGRI with construction and checking of pedigree files, checking genotype and trait data for errors (using sophisticated computer programs), estimating allele frequencies, performing linkage and association analyses, and constructing haplotypes to narrow the region where the putative gene may exist. This work requires strong computer skills and high level knowledge of a broad array of statistical genetics techniques and computer programs. The successful Offeror must: a.Have a B.S. in Mathematics or a related field. b.Have a M.S. in Computer Applications or an M.S. in Applied Statistic c.Have experience working on a genome-screen d.Have a background in statistics with training in genetics. e.Have experience in conducting research in genetic epidemiology, f.Have experience working as a statistical geneticist/technical analyst. g.Have experience with programs used for statistical genetic analysis such as SAS, S-PLUS, R, SIMCA, SLINK, GAS, LINKAGE, MERLIN, and GENEHUNTER, and is proficient in computer programming in C++, Java, C, HTML, PERL, XML, PL/SQL. D. REPORTING REQUIREMENTS AND DELIVERABLES The contractor will work with the Inherited Disease Research Branch staff on a weekly basis. He/she will communicate progress and provide summary of activities, either orally or in writing, to Principal Investigator on a quarterly basis, at a minimum. In actual practice, the Principal Investigator and the contractor will probably be in contact by telephone or email at least on a weekly basis. In addition to the quarterly progress report, the contractor will deliver the data analyses as they are completed. The contractor will meet the principal investigator at a scientific meeting or at the NIH as needed for planning and development of the data analysis efforts. E. PERIOD OF PERFORMANCE AND LEVEL OF EFFORT The overall estimated period of performance for the contract will be twelve months at 100% effort. F. PROGRAM MANAGEMENT AND CONTROL REQUIREMENTS The contractor will work independently with no direct supervision by any government employee. The study Principal Investigator and other research team members will provide guidance in terms of technical reporting needs and study requirements of the project supported, plus frequent email and telephone guidance concerning the design and conduct of the analyses and the interpretation of the results. G. GOVERNMENT RESPONSIBILITIES The contractor will provide his own supplies and space to work. The government will loan necessary PC computer equipment to the contractor in order to ensure that all government data are stored only on government computers and that all government-required security procedures are followed. The contractor will also have access to government-owned high-speed computer servers at NHGRI so that the analyses can be completed in a timely manner in a secure environment. On occasions when collaborative efforts will occur when the contractor is visiting NHGRI, the contractor will have temporary use of government space and computer equipment on an as-needed basis. H. INSPECTION AND ACCEPTANCE CRITERIA As plans are developed the contractor will provide draft documentation, reports, and progress of the work. The Principal Investigator will review, inspect, and approve all documentation to ensure that work is in line and following the objectives of the study. I.EVALUUATION CRITERIA 1. Technical Approach. Have well documented experience working on a genome-screen, must have statistical, technical, and administrative knowledge necessary to provide deliverables. Have well documented experience in conducting research in genetic epidemiology. (60 points) 2.Past Performance. Contractor shall have a master’s degree with extensive education and knowledge of computer application and applied statistics as used in statistical genetic. Contractor shall have strong experience with programs used for statistical genetic analysis. Contractor should have strong communication skills and the ability to work collaboratively. (40 points) The Offeror must include a completed copy of the following provisions: 1) FAR Clause 52.212-1 Instructions to Offerors Commercial; 2) FAR Clause 52.212-2, Evaluation Commercial Items. As stated in FAR Clause 52.212-2 (a), The Government will award a contract resulting from this solicitation to the responsible offeror whose offer conforming to the solicitation will be most advantageous to the Government, price and other factors considered. The following factors shall be used to evaluate offers: Technical Evaluation and Price. 3) FAR Clause 52.212-3, Offeror Representations and Certifications Commercial Items; 4) FAR Clause 52.212-4, Contract Terms and Conditions Required To Implement Statues or Executive Orders Commercial Items, Contract Terms and Conditions Commercial Items; and 5) FAR Clause 52.212-5, Contract Terms and Conditions Required to Implement Statutes or Executive Orders Commercial Items Deviation for Simplified Acquisitions. The offeror must include in their quotation, the unit price, the list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Dun & Bradstreet Number (DUNS), the Taxpayer Identification Number (TIN), and the certification of business size. Note: In order to receive an award from the NHLBI contractors must have a valid registration in the Central Contractor Registration (CCR) www.ccr.gov and ORCA https://orca.bpn.gov/. The clauses are available in full text at http://www.arnet.gov/far. Quotes are due April 12, 2010 by 12:00 pm Eastern Standard Time. The award will be made based upon the requirements specified in this combined/synopsis, and to the offeror providing the best value in meeting the Government's requirements. The offerors must provide documentation in support of the specified requirements. The Government intends to evaluate offerors and may award a contract without discussions with Offerors. Therefore, the initial offer should contain the offerors best terms from a technical and price standpoint. However, the Government reserves the right to conduct discussions if later it is determined by the Contracting Officer to be necessary. The Government may reject any or all offers, waive informalities and minor irregularities in offers received. The proposal must reference the Solicitation number NHLBI-PB-(HG)-2010-125-RSF. All responsible sources may submit a proposal which if timely received shall be considered by the agency. Proposals must be submitted electronically (via email) to Rashida Ferebee, Contract Specialist, at ferebeers@nhlbi.nih.gov in either MS Word or Adobe Portable Document Format (PDF) by the date and time specified above. All responses must be received by the specified due date and time in order to be considered.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NHLBI/NHLBI-PB-(HG)-2010-125-RSF /listing.html)
- Place of Performance
- Address: Bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN02112698-W 20100407/100405234752-05ab6d175fa758e73e8efce09ffe7208 (fbodaily.com)
- Source
-
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