SOURCES SOUGHT
A -- Mouse Model Repository
- Notice Date
- 1/25/2010
- Notice Type
- Sources Sought
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch, 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, Maryland, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- SS-NICHD-CDBPM-10-11
- Archive Date
- 2/26/2010
- Point of Contact
- Katharine Minker, Phone: 301-402-7571, Ross Kelley, Phone: 301-435-6960
- E-Mail Address
-
km571h@nih.gov, rk17a@nih.gov
(km571h@nih.gov, rk17a@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- Description This announcement is not a Request for Proposals (RFP) and does not commit the Government to award a contract now or in the future. No solicitation is available at this time. The purpose of this synopsis is to identify small business organizations with requisite qualifications to provide the services stated herein. Based on capability statements received in response to this Sources Sought Announcement this acquisition may be solicited as a 100% small business set-aside. All small business organizations (SB, SDB, WOSB, HUBZone, VOSB, and SDVOSB) are encouraged to respond to this notice. This requirement is assigned a code of 541711 in the North American Industry Classification System (NAICS), and the size standard for such requirements is 500 employees. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/NIH, seeks capability statements from interested and qualified potential sources to continue operations of the Mouse Model Repository for Cytogenetic Disorders. The objective will be to produce, maintain, and distribute aneuploid mice with a primary emphasis on chromosome 16 as a model of human trisomy for chromosome 21. Projected requirements: 1) Maintenance of the “Repository for Mouse Models of Cytogenetic Disorders” or “Cytogenetic Resource”. 2) Breed various strains of mice with known genetic background, which will produce chromosomally unbalanced gametes, resulting in trisomic and monosomic embryos with special emphasis on chromosome 16, but including relevant regions of chromosome 17 and chromosome 10. 3) Refine procedures to cryopreserve embryos that will be rescued by thawing and re-implanting them in pseudo-pregnant mice. The Contractor should evaluate the fertility of both male and female mice for optimal methods of maintaining individual mouse strains at least semiannually. 4) Distribute the animal models to qualified investigators approved by the NICHD. 5) Test the animals periodically for pathogens. 6) Publicize the availability of mouse models indicating the type of strains in the colony as well as detailed information about the strain phenotype, genotype, protocols for genotyping, husbandry conditions, and other details as specified by the Project Officer. This information should be made available via the internet. 7) Continue to characterize the clinical and behavioral phenotype of the mouse models to ensure integrity of the strains, especially for any new strains offered by the Contractor or as specified by the Project Officer. Capability Statement/Information Sought: Organizations that submit capability statements in response to this notice will be evaluated against the following technical areas of experience and expertise: 1.Experience: Provide evidence of successfully breeding, maintaining, and distributing mice that produce partial trisomy with special emphasis on the Ts65Dn mouse strain. Provide successful documentation of the phenotypic and behavioral equivalence of the Ts65Dn strain in which the Pde6brd1 (retinal degeneration) gene has been successfully removed to the original Ts65Dn strain, for large-scale future distribution and a plan to effect this transition. In addition, evidence of successfully cryopreserving embryos and implanting them into pseudo-pregnant mice to produce viable progeny should also be provided. Provide documentation of prior ability to maintain mice in a healthy, pathogen-free state. 2.Facilities: The offeror must demonstrate that it has facilities and equipment for breeding, maintaining, and distributing mice that produce partial trisomy, including adequate computer documentation and processing of requests, and a system for timely completion of orders for mice. 3.Other specific capabilities to be demonstrated are: the ability to identify, maintain, and breed mice carrying balanced Robertsonian fusion chromosomes producing whole chromosome aneuploidies and partial trisomies involving chromosome 16, and when available, chromosomes 10 and 17. The offeror must have reliable, cost-effective protocols for genotyping mice. Interested organizations that believe they possess the capabilities necessary to undertake this project should submit an electronic copy in addition to four (4) hard copies of their capability statement, addressing the areas above. Please limit responses to fifteen (15) pages or less. Any proprietary information should be so marked. Written capability statements should be received by the Contracting Officer by no later than 3:00PM local time on February 11, 2010. Capability statements must identify the business status of the organization (e.g., educational institution, non-profit, large business, small business, 8 (a), or other corporate or non-corporate entity). NO COLLECT CALLS WILL BE ACCEPTED. RESPONDENTS MAY SUBMIT THEIR CAPABILITY STATEMENTS VIA E-MAIL IN ADDITION TO THE 4 HARD COPIES. Responses should be no more than 15 pages. These pages exclude resumes. INQUIRIES Katharine Minker, Contract Specialist Eunice Kennedy Shriver National Institute of Child Health and Human Development Office of Acquisitions, NICHD Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510 Bethesda, Maryland 20892-7510 Rockville, MD 20852 (for express/courier service) km571h@nih.gov Phone: 301-402-7571 Fax: 301-402-3676 OR Ross Kelley, Contracting Officer Eunice Kennedy Shriver National Institute of Child Health and Human Development Office of Acquisitions, NICHD Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510 Bethesda, Maryland 20892-7510 Rockville, MD 20852 (for express/courier service) Phone: 301-435-6960 Fax: 301-402-3676 rk17a@nih.gov
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NICHD/SS-NICHD-CDBPM-10-11/listing.html)
- Record
- SN02049146-W 20100127/100125234738-69b5852cb863de2b8f630456e664f257 (fbodaily.com)
- Source
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