SOLICITATION NOTICE
B -- Questionnaire Data and Biosamples on Mate Consumption and PAH Exposure in Esophageal Tissues
- Notice Date
- 8/20/2009
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-90206-NG
- Archive Date
- 9/19/2009
- Point of Contact
- Malinda L Holdcraft, Phone: (301) 402-4509, Caren N Rasmussen, Phone: (301) 402-4509
- E-Mail Address
-
holdcram@exchange.nih.gov, cr214i@nih.gov
(holdcram@exchange.nih.gov, cr214i@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI), Division of Cancer Epidemiology and Genetics (DCEG), Nutritional Epidemiology Branch (NEB) plans to procure on a sole source basis Questionnaire Data and Biosamples on Mate Consumption and PAH Exposure in Esophageal Tissues from Fundacao de Apoio a Technologia e Ciencia (FATEC), Universidade Federal de Santa Maria, Rua Q, Predio 66 – Faixa de Camobi, Santa Maria, RS 97105-900, Brazil. The supplies herein are being procured in accordance with the simplified acquisition procedures authorized by FAR Part 13. The North American Industry Classification System Code is 541990 and the business size standard is $7M. The period of performance shall be twelve (12) months from date of award. For the past 20 years, investigators in the Nutritional Epidemiology Branch (NEB) of the Division of Cancer Epidemiology and Genetics at NCI have conducted research on the etiology of esophageal cancer in areas of the world that have an especially high-risk for this disease. Rio Grande do Sul Province (RS), Brazil, is a high-risk area for esophageal cancer. Previous studies in RS have shown that mate, an herbal drink frequently consumed there, is an important risk factor for esophageal cancer in this area. Recently, NEB researchers have shown that commercial mate contains large quantities of polycyclic aromatic hydrocarbons (PAHs), probably due to contamination during the processing of the mate leaves, and this may be one reason why mate drinking is associated with increased esophageal cancer risk. Another recent NEB study, from a high-risk population in Iran, stained normal esophageal biopsy tissue from esophageal cancer patients and control subjects with an antibody raised against a PAH compound and found a strong dose-response relationship between antibody staining and esophageal cancer case status, suggesting that PAH exposure, measured in the target organ, was strongly associated with esophageal cancer development. The primary purpose of this procurement is to evaluate the association between mate consumption and PAH exposure in esophageal tissue among inhabitants of RS who do not have esophageal squamous dysplasia or cancer. Secondary objectives include evaluation of the association of mate consumption and other measures of PAH exposure and susceptibility, including urine1-hydroxypyrene glucuronide (1-OPHG, a stable metabolite of PAHs) and polymorphisms of PAH metabolizing genes. The Federal University of Santa Maria (Universidade Federal de Santa Maria – UFSM) in Santa Maria, RS, recently completed a study in which they collected mate consumption and other data by questionnaire and biosamples including saliva (a DNA source), urine, and endoscopic biopsies from normal-appearing esophageal mucosa from RS residents who were undergoing esophageal endoscopy for clinical reasons unrelated to esophageal cancer. Under this contract, the NCI will purchase the questionnaire data and biosamples so that the mate-PAH associations listed above can be evaluated. Heavy mate drinking is limited to certain areas of South America, including Rio Grande do Sul Province in southern Brazil. The study described above, collecting the data and biospecimens needed by NCI to compare mate consumption and PAH exposure in esophageal biopsies, was conducted by the Universidade Federal de Santa Maria (UFSM), so UFSM is the only source for NCI to obtain the required data and specimens. FATEC is the part of UFSM from which the data and samples can be purchased. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NCI to determine if the party can meet this requirement. One (1) original and one (1) copy of the capability statement must be received in the contracting office by 11:00 a.m. ET on September 4, 2009. All questions must be in writing and can be faxed to 301-402-4513 or sent via email to Malinda Holdcraft: holdcram@exchange.nih.gov. It is the vendor’s responsibility to ensure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted. In order to receive an award, contractor must have valid registration and certification in the Central Contractor Registration (CCR) and the Online Representations and Certifications Application (ORCA). Please reference NCI-90206-NG on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/NCI-90206-NG/listing.html)
- Record
- SN01920931-W 20090822/090821002345-c5a429223b547f7ea6eff32b0d16b942 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
| FSG Index | This Issue's Index | Today's FBO Daily Index Page |