SOLICITATION NOTICE
R -- Genoptyping services
- Notice Date
- 8/11/2009
- Notice Type
- Presolicitation
- NAICS
- 541990
— All Other Professional, Scientific, and Technical Services
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Station Support/Simplified Acquisitions, 31 Center Drive, Room 1B59, Bethesda, Maryland, 20892
- ZIP Code
- 20892
- Solicitation Number
- NOI-1190752
- Archive Date
- 9/4/2009
- Point of Contact
- Liem T Nguyen, Phone: 3014358780
- E-Mail Address
-
ln18x@nih.gov
(ln18x@nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Institute of Health (NIH), National Institute on Drug Abuse (NIDA) Office of Acquisitions, Station Support Simplified Acquisitions Branch on behalf of the National Institute of Neurological Disorders and Strokes (NINDS) intends to negotiate, on a sole source basis, with Johns Hopkins Hospital, Baltimore, Maryland, under the authority of FAR 13.106-1(b)(1) for genotyping service. The North American Industry Classification System Code is 541990 and the business size standard is $7.0M. One of the missions of the NINDS Surgical Neurology Branch (SNB) is to make significant advances beyond the present state of knowledge in the field of Chiari I malformation and syringomyelia. The Branch's research laboratories and Clinical Branches study the fundamental mechanisms of certain diseases of the nervous system, including Chiari I malformation. One clinical research protocol of the Branch explores the mechanism of inheritance of Chiari I malformation. Researchers collect and study families in which Chiari I malformation is inherited and use DNA-based diagnostics to search for a genetic mutation associated with familial Chiari I malformation. The discovery of a gene mutation for familial Chiari I malformation would provide insight into the pathogenesis of sporadic Chiari I malformation, which is more frequent. This proposed acquisition is a part of a continued collaborative effort under protocol 00-N-0089, Genetic Analysis of the Chiari I Malformation. Researchers at NINDS and Kazan State Medical University, Russia, have collected 122 blood samples, family histories, and medical histories from families affected by Chiari I malformation in Russia. In addition, NINDS researcher has collected 15 blood samples, family histories, and medical histories from families affected by Chiari I malformation in the United States. These researchers have agreed to collaborate with researcher at the Statistical Genetics Section, National Human Genome Research Institute (NHGRI) to attempt to identify genes that increase the risk for Chiari I malformation. They have shared the DNA and data collected on these individuals (no personal identifiers) for previous studies. Now these 137 samples will be genotyped using the Illumina HumanOmni1-Quad Array chip, a panel of over 1 million SNP markers. The researchers will then collaboratively analyze these data from the unique founder population in Russia and from families affected by Chiari I malformation in the United States. The purpose of this procurement is to obtain service from a vendor with experience in providing high-throughput, high-quality genotyping of 137 DNA samples from members of families affected by Chiari I malformation using a SNP Human Whole Genome Association Study chip with over 1 million SNP markers. In addition, three (3) blind duplicates will be necessary for quality control purposes. NINDS will provide the DNA samples to the Johns Hopkins Hospital Core Lab (JHCL) in the appropriate format. The JHCL will perform the genotyping and quality-control error checking and will return the resulting genotypes in computer-readable files to the collaborators and will also return any remaining DNA to NINDS. The vendor will engage in several activities, including working with the researchers to prepare the family structure files, genotyping the samples, quality control, allele-calling, and reporting of final genotype data. The contractor will communicate progress and provide summary of activities, either orally, by email or in writing, to the Principal Investigator and Associate Investigator when quality control testing is completed, when genotyping is completed and when genotypes are ready for export. The final report will include the genotype data, summaries of quality control measures, dropped markers, and marker maps. The period of performance is for 90 days from the date of award. No solicitation package will be issued. This notice of intent is not a request for competitive quotations; however, interested party believes it can meet the above requirement may submit a statement of capabilities to Liem T Nguyen, ln18x@nih.gov on or before 3:00 PM ET August 20, 2009. All information furnished must be in writing and must contain material in sufficient detail to allow the government to determine if the party can perform the requirement. A determination by the Government not to compete this proposed acquisition based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. In order to receive an award, contractors must be registered in and have valid certifications in the Central Contractor Registration (CCR), www.ccr.gov and the Online Representations and Certifications Application (ORCA) www.orca.bpn.gov. Please reference announcement number NOI-1190752 on all correspondence.
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/NIDA-2/NOI-1190752/listing.html)
- Place of Performance
- Address: bethesda, Maryland, 20892, United States
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN01906870-W 20090813/090812000117-6dc2f702156455323288c8f096ea685e (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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