MODIFICATION
B -- Evaluation of the Efficacy and Immunogenicity of Vaccinia Virus-Based Vaccine Against Bacillus Anthracis
- Notice Date
- 5/15/2009
- Notice Type
- Modification/Amendment
- NAICS
- 541380
— Testing Laboratories
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Office of Acquisitions, 6120 Executive Blvd., EPS Suite 600, Rockville, Maryland, 20852
- ZIP Code
- 20852
- Solicitation Number
- N02-RC-81032-83
- Response Due
- 12/18/2008
- Archive Date
- 7/16/2009
- Point of Contact
- Michael P. Marino, Phone: 3014353801, Richard L. Hartmann, Phone: 3014968620
- E-Mail Address
-
marinomic@mail.nih.gov, hartmari@mail.nih.gov
(marinomic@mail.nih.gov, hartmari@mail.nih.gov)
- Small Business Set-Aside
- N/A
- Description
- The National Cancer Institute (NCI) is seeking a contractor to provide testing of a proposed new anthrax vaccine. The Metabolism Branch, NCI has developed a safer and more immunogenic vaccine candidate against anthrax by integrating a codon-optimized gene encoding the protective antigen (PA) of Bacillus anthracis into the genome of Dryvax (Wyeth) vaccinia strain and Modified Virus Ankara (MVA) strain of vaccinia virus. The purpose of this procurement is to ascertain the efficacy of this NCI-owned vaccine against an experimental challenge of B. anthracis in a specific rabbit model of disease and it is necessary for the government to correlate immunological findings of the NCI owned vaccine candidate against anthrax with results from other completed studies. This challenge study will provide critical information as to the immunogenicity, reactogenecity and correlates of immunity for these anthrax vaccines in an appropriate, validated small animal model (Hermanson, G. et al PNAS, 2004, 101: 13601-13606), a required step before a vaccine could be used in people. It is critical that the facility performing this evaluation is experienced with the complex methodology of procuring and housing rabbits under appropriate conditions for aerosol inoculation with the targeted B. anthracis spore (Ames strain) inhaled dose. The facility performing this testing must be able to provide a validated stock of known lethal dose titrer B. anthracis spores for the aerosol inoculation required and to perform bacteremia evaluations on serum after bleeding the injected rabbits from an auricular artery or vein. The Government anticipates that one (1) cost-plus-fixed-fee type contract will be awarded for a period of four (4) months. The anticipated solicitation issue date is approximately on or around June 1, 2009, and proposals will be due approximately 30 calendar days after the solicitation issue date. The RFP will be available at the website of the Office of Acquisitions (OA), NCI, at the following url: http://rcb.cancer.gov/rcb-internet/appl/rfp/published_rfps.jsp. IT IS THE OFFEROR'S RESPONSIBILITY TO MONITOR THE ABOVE INTERNET SITE FOR THE RELEASE OF THE SOLICITATION AND ANY AMENDMENTS. The NAICS Code is 541380 with a size standard of $12 million per annum. Based upon market research, the Government is not using the policies contained in Part 12, Acquisition of Commercial Items, in its solicitation for the described supplies or services. Point of contact is Michael P. Marino; electronic mail address: marinomic@mail.nih.gov ; telephone: (301)435-3801; fax: (301)402-6699. Collect calls will not be accepted. Added: <input type="hidden" name="dnf_class_values[procurement_notice][description][1][added_on]" value="2008-12-04 14:13:35">Dec 04, 2008 2:13 pm Modified: <input type="hidden" name="dnf_class_values[procurement_notice][description][1][modified_on]" value="2009-05-15 13:01:20">May 15, 2009 1:01 pm Track Changes
- Web Link
-
FBO.gov Permalink
(https://www.fbo.gov/spg/HHS/NIH/RCB/N02-RC-81032-83/listing.html)
- Place of Performance
- Address: To be negotiated, United States
- Record
- SN01820132-W 20090517/090516161906-64684210f903c820c14d94d0333806b8 (fbodaily.com)
- Source
-
FedBizOpps Link to This Notice
(may not be valid after Archive Date)
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