SOLICITATION NOTICE
66 -- 18672700 PUMP P960
- Notice Date
- 8/26/2008
- Notice Type
- Presolicitation
- NAICS
- 541711
— Research and Development in Biotechnology
- Contracting Office
- National Institutes of Health6707 Democracy BlvdTwo Democracy Plaza RM770ABethesdaMD20892-7511
- ZIP Code
- 20892-7511
- Solicitation Number
- NICHD2008018
- Response Due
- 9/9/2008
- Archive Date
- 10/9/2008
- Point of Contact
- SAGNA, NYDIA N +1 301 402 1517, sagnan@mail.nih.gov<br />
- Small Business Set-Aside
- N/A
- Description
- The National Institutes of Health (NIH), National Institute of Child Health and Human Development (NICHD) intends to procure from GE Healthcare BioSciences, 800 Centennial Ave Piscataway, NJ 08855 a quantity of one (1) AKTA Purifier System to include the following parts (P/N 18672700 Pump P-960, P/N 18117584 Air Sensor A-912N Kit, P/N 28404473 Bufferprep Kit, P/N 18113484 PH Electrode Round Tip, P/N 18111103 Dummy PH Electrode, P/N 18608300 FRAC 950, P/N 18111247 Teflon Tubing 1/8 (3/16), P/N 18111248 Ferrules For 3/16 OD Tubing Peek, P/N 18111249 NUT, 3/16 For Inlet Tubing, P/N 18111315 Inlet Filter Assembly Complete, P/N 18115424 Akta User Kit, P/N 17524701 HiStrap HP 5X1 ML, P/N 17519001 HiPrep 16/10 Q FF, P/N 17519201 HiPrep 16/10 SP FF, P/N 17099801 Heparin Sepharose 6 FF, 50ML, P/N 18877301 Column XK 16/20, P/N 18100072 XK 26/20, P/N 28406415 Tricorn 10/100 Column, P/N 18877801 Flow Adaptor AK16, P/N 135682401 (S) Aktapurifier UPC 100 w/Laptop Control. The Institute intends to procure this system under the authority of the Federal Acquisition Regulations (FAR) 6.302. GE Healthcare BioSciences is the sole authorized distributor of the AKTA Purifier UPC System This system will be used to purify biomolecules from complex starting materials. The contractor shall provide a system:1)able to perform separations based on a variety of sample characteristics, such as molecular weights, net surface charge, hydrophobicity, while retaining biological activity. 2)With a flow rate range of.01-100 mls/min at pressures ranging from 0-10 MPa (1450psi)3)With a two-pump gradient system, with dynamic mixing.4)The wetted flow path inert to halides. The pump heads must be titanium with valves and tubing in PEEK.5)Pumps should allow operation of the system at zero backpressure to ensure system compatibility with standard low-pressure chromatography supports often used in affinity chromatography and other techniques.6)The controller must allow programs to be time-based, volume-based, or column-volume based.7)Should include the option of a fraction collector that is fully integrated into the system and fully controllable via the system control software. This fraction collector must have the capacity to fractionate into 175x 12-mm diameter tubes or 95x 10-18mm tubes.8)Should include a motorized valve for sample injection. The system must have the ability to control 8 more motorized valves for a total 9 motorized valves. The motorized valves should provide feedback to the control system to ensure proper orientation of all valves. The valves should be driven electronically and require no external air or pressure to operate.9)The system controller must allow the user to be entering details of the next purification at the same time the current separation is being done, or to simultaneously be integrating and evaluating the results of earlier runs. The software must allow complete manual control of all parameters and running conditions while running a method.10)Control of motorized valves, fraction collector, dynamic gradient mixer, and autosampler must all be possible from the system controller.11)The controller must accept seven input signals (e.g. UV wavelength, conductivity, pH, temperature, pressure). It must be capable of plotting, and integrating these signals, as well as using them to trigger sub-routines in the programming when the signal exceeds a present threshold, to allow the automation of multi-dimensional separations.12)The system must include one automatic three-position injection valve (load, inject, and wash positions), which will allow for sample loading onto the column.13)The system controller should allow for automation of the optimization of separation parameters (e.g. sample volume, flow rate, gradient slope). This should allow a small amount of sample to be consumed in optimizing the purification scheme, after which the best regime can be scaled up on the same LC system.14)Column equilibration before and after sample injection and elution must be capable of being monitored, with a feed-back loop to the control system, so we can be certain equilibration is completed, without consuming, excess volume of sometimes expensive buffers.15)Documentation of each run should be automatic and exhaustive, so that for purposes of subsequent replication and eventual publication, no detail is left unrecorded. Access to the controller must be by user name with password and level of access by each user must be definable administrator. Post-run chromatographic analysis and reporting functions should also be included.16)The system must have a definable pressure limit system defined when the column is selected from a list which will stop the pump and generate an audible and visual warning, in the event pressure exceeds the preset limit. The controller should allow the user the option of including in his/her chromatographic methods programs, commands which will automatically reduce the flow rate if an over-pressurization occurs as sample is being applied or eluted from the column. Additional variables which should also be programmable to trigger sub-routines (e.g. new tube on fraction collector; valve changes; etc.) should include UV or conductivity signals. The controller must turn off the pump flow when a signal is received from the fraction collector indicating there are no tubes remaining, so that valuable sample is preserved.17)The system must automatically and continuously be able to record throughout each chromatographic run the following parameters; flow rate; UV signal; actual AND programmed conductivity of the eluent; eluent pH; system pressure; accumulated time of run; all valve positions and changes in position; activity of a fraction collector- and it must allow these recorded data to be called up later for interpretation and to aid in future replication of results. It must allow for post-run analysis of chromatograms, export of data to other spreadsheet programs, and generation of written reports.18)Set-up and training must be provided by the vendor. This is not a solicitation for competitive proposals. However, if any other interested party believes that it can meet the requirements it may submit a statement of capabilities. The capability statement and any other information furnished must be in writing and must contain material in sufficient details to allow NIDDK to determine if the party can meet all of the foregoing requirements. Offers must also be accompanied by descriptive literature, warranties and/or other information that demonstrates that the offer meets all of the foregoing requirements. An original and one copy of the capability statements and related materials must be received in this office by 3:00p.m. EST on or before September 9, 2008. Faxed and emailed capability statements are NOT authorized. A determination by the Government not to compete this proposed acquisition is based upon responses to this notice and is solely within the discretion of the Government. Request for copies of the Request for Quotation (RFQ) shall be emailed to Nydia Sagna @ sagnan@mail.nih.gov or faxed to 301-480-4226. It is anticipated that RFQ# NICHD2008018 will be available fifteen (15) days after the publication date of this synopsis. Receipt of quotations will be due ten (10) days after the release of the RFQ. NOTE: In order to receive an award from the NIDDK, contractors must be registered in the Online Representations and Certifications Applications (ORCA). Please refer to http://orca.bpn.gov in order to register. In addition, contractors must have a valid registration in the Central Contractor Registration (CCR) www.ccr.gov
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