SOLICITATION NOTICE
A -- Studies of Immunosenescence and Other Late Effects of Acute Ionizing Radiation Exposure
- Notice Date
- 7/1/2008
- Notice Type
- Presolicitation
- NAICS
- 541712
— Research and Development in the Physical, Engineering, and Life Sciences (except Biotechnology)
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Office of Acquisitions, 6700 B Rockledge Room 3214 MSC7612, Bethesda, Maryland, 20892-7612
- ZIP Code
- 20892-7612
- Solicitation Number
- RFP-NIAID-DAIT-NIHAI2008023
- Response Due
- 8/14/2008
- Point of Contact
- Donald E Collie,, Phone: 301-496-0992
- E-Mail Address
-
dcollie@niaid.nih.gov
- Small Business Set-Aside
- N/A
- Description
- Introduction: The National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), of the Department of Health and Human Services (DHHS) supports research related to the basic understanding of microbiology and immunology leading to the development of vaccines, therapeutics, and medical diagnostics for the prevention, treatment, and diagnosis of infectious and immune-mediated diseases. The NIAID, Division of Allergy, Immunology, and Transplantation (NIAID/DAIT) has a requirement to identify, characterize, and develop new medical countermeasures against radiological or nuclear attacks. Description: NIAID/DAIT plans to issue a Request for Proposal (RFP) to the Radiation Effects Research Foundation of Japan. If the need arises, an Offeror would conduct research on radiation-induced immune system aging (immunosenescence) and other late effects of radiation to determine the effects of radiation and aging on the immune and other organ systems and the contribution of such effects to disease development in persons exposed to an atomic bomb explosion. The Offeror would conduct research to understand the mechanisms of radiation and aging and how these factors impact immune aging, to determine the relationship between immune dysfunction and a persistent inflammatory state, and the resulting diseases and infections that may occur with immunosenescence in those who survived an atomic bomb explosion. The Offeror would use specimens obtained from atomic bomb survivors and perform correlative basic science studies in animal models to elucidate the underlying mechanisms of radiation-induced immunosenescence. The Offeror, if awarded, would be required to analyze the effects of ionizing radiation exposure and aging on the hematopoietic stem cells; analyze the effects of ionizing radiation on dendritic cells and their precursors; analyze the effects of ionizing radiation exposure and aging on vaccination responses and investigate methods to augment a robust immune response; develop a comprehensive scoring system for human immune competence as it relates to age and ionizing radiation. Offeror would be required, for example, to demonstrate and document the following: 1. Demonstrated history of tracking for decades the long-term health status of tens of thousands of individuals including men and women from all age groups who were exposed to nuclear weapon-associated ionizing radiation of varying degrees. 2. Demonstrated history of conducting prospective and retrospective clinical and basic research studies in atomic-bomb survivors. 3. Access to survivors, databases, and tissue samples (e.g., blood) of atomic-bomb survivors. 4. Demonstrated history of conducting research in atomic-bomb survivors and the impact radiation on the immune system in this population. 5. Personnel/Management: adequacy, appropriateness and relevance of expertise, experience, qualifications, and availability of the key professional and technical staff with a project of similar size, scope, and complexity. It is anticipated that cost reimbursement, completion type contract shall be awarded to a single contractor for a 5-year period of performance beginning on or about July 15, 2009, pending the availability of funds and receipt of technically acceptable proposals from the contractor. The estimated FTEs would be approximately 9.2, inclusive of work subcontracted to institutions within the United States. In addition, the Offeror will provide a proposal to accomplish the above requirements for the 5 year period of planned funding. If desired, the Offeror will at the time of proposal incorporate the Option to develop additional projects in the field of radiation-induced immunosenescence and/or other late effects of radiation in atomic bomb survivors. Since research is an evolving process, additional funding for FTEs may be required pending the need and the availability of funding. The proposal would be evaluated according to the following criteria: (1) Technical Plan/Approach, (2) Scientific and Technical Personnel, (3) Facilities, Equipment, and other Resources, and (4) Project Management. The anticipated release date of the RFP is on or about August 25, 2008, with an anticipated offer due date on or about January 25, 2009. The firm date of receipt of offers will be stated in the RFP. This notice does not commit the Government to award the contract. No collect calls or facsimile transmissions will be accepted.
- Web Link
-
FedBizOpps Complete View
(https://www.fbo.gov/?s=opportunity&mode=form&id=9ac8ac5dbf8597133efd0cd353c5cbd1&tab=core&_cview=1)
- Record
- SN01605095-W 20080703/080701221957-9ac8ac5dbf8597133efd0cd353c5cbd1 (fbodaily.com)
- Source
-
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