SOLICITATION NOTICE
R -- Physiologically-Based Pharmacokinetic (PBPK) Modeling Technical Support
- Notice Date
- 4/14/2008
- Notice Type
- Presolicitation
- NAICS
- 541620
— Environmental Consulting Services
- Contracting Office
- Environmental Protection Agency, Office of Acquisition Management, EPA/Ohio, Cincinnati Procurement Operations Division 26 W. Martin Luther King Drive Cincinnati, OH 45268
- ZIP Code
- 45268
- Solicitation Number
- PR-CI-08-10211
- Response Due
- 5/14/2008
- Point of Contact
- MatthewGrowney,, Phone: (513) 487-2029
- E-Mail Address
-
growney.matthew@epa.gov
- Description
- The US Environmental Protection Agency (EPA) is increasingly using physiologically-based pharmacokinetic (PBPK) models in risk assessments, and is in need of technical support, especially for work conducted within the Office of Research and Development (ORD). The objective of this solicitation is to provide technical support for the Agency?s evaluation, development, modification, and application of PBPK models to derive health-based reference values. The US EPA is charged with conducting human health risk assessments to provide decision makers with the scientific information they need to make informed decisions about actions that may be taken to protect human health. Risk assessment activities involve quantitative characterizations of dose-response relationships for adverse effects following human exposure, and the derivation of reference values for ?safe? levels of exposure that are used to protect the public health. PBPK models provide a chemical- specific quantitative characterization of a chemical?s toxicokinetics, and if adequately developed and tested, have the potential to replace uncertainty factors when estimating internal dose in different species (i.e., test animals and humans) resulting from a variety of exposure regimens. As such, PBPK models are increasingly being used in the derivation of reference values either to replace the non-chemical-specific uncertainty factors (e.g., to account for uncertainties in interspecies extrapolation and intraspecies variability) or to bridge data gaps where no uncertainty factors exist (e.g., route-to-route extrapolation; exposure duration extrapolation). The Government anticipates award of a cost plus fixed fee term (LOE) contract with a twelve-month base term and four (4) twelve month options to extend the term. The base level of effort for each term will consist of 5,870 direct labor hours. The Government anticipates including quantity option amounts of 50% for the Base and the option periods, which brings the maximum total potential on the contract to 44,025 direct labor hours over five (5) years. The solicitation will be issued on a full and open competitive basis; it will not be a small business set-aside. Copies of the solicitation will be available to all offerors on the Internet at the following website: http://www.epa.gov/oam/cinn_cmd. Interested parties are expected to download the solicitation and subsequent amendments from the website and to monitor the status of the RFP. All responsible sources may submit a proposal which will be considered by EPA. The anticipated solicitation release date is mid May and the close date shall be approximately 30 days thereafter. Contract award will be made in accordance with Far Part 15, Contracting by Negotiation. The NAICS code is 541330, Environmental Consulting Services, with a size standard of 6.5 million maximum annual receipts. The point of contact for this procurement is Matthew J. Growney at 513-487-2029. See Note 26.
- Web Link
-
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- Record
- SN01553384-W 20080416/080414215902-face1eca190da9b2f1752f81f8396ba4 (fbodaily.com)
- Source
-
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