Loren Data's SAM Daily™

FBO DAILY ISSUE OF NOVEMBER 11, 2006 FBO #1811
SOLICITATION NOTICE

66 -- Notice of Intent to award a sole source procurement

Notice Date

11/9/2006
 

Notice Type

Solicitation Notice
 

NAICS

339111 — Laboratory Apparatus and Furniture Manufacturing
 

Contracting Office

US Army Medical Research Acquisition Activity, ATTN: MCMR-AAA, 820 Chandler Street, Frederick, MD 21702-5014
 

ZIP Code

21702-5014
 

Solicitation Number

W23MYC6227N035
 

Response Due

11/27/2006
 

Archive Date

1/26/2007
 

Small Business Set-Aside

N/A
 

Description

SUBJECT: NOTICE OF INTENT TO AWARD A SOLE SOUCE PROCUREMENT DESC: Under the authority of FAR 6.302-1, it is the Governments intent to award a sole source to Biacore, Inc. for purchase of a Biacore T100 Processing Unit. Failure to purchase this pa rticular item would result in time-consuming exploration and validation of new standard protocols, as well as additional training for personnel. Experimental designs routinely performed using Biacores patented chip surfaces may not translate to alternati ve technologies, making reproduction of existing results impossible. This is not a formal solicitation. This synopsis is not considered a Request for Quotation or Proposal. No solicitation document is available and telephone requests will not be honored . No contract will be awarded on the basis of offers received in response to this notice. Any response to this notice must show clear and convincing evidence that competition would be advantageous to the Government. If no affirmative written response is received, the purchase will be awarded without further notice. A determination by the Government not to compete this proposed contract based on this notice is solely within the discretion of the Government. Detailed capabilities must be submitted to the following email address no later than 1:00 p.m., Eastern Standard Time 27 November 2006. Email: jeff.ingram@amedd.army.mil Please see Characteristics of this item below. unique characteristics of this instrument: ? Sensitive SPR optical detection capable of making reliable direct, real-time, label free measurements on as little as a few picograms of bound material, and detecting direct measurements of molecules as small as 150 Daltons. ? Patented multichannel (up to 4 flow-cells) micro-fluidics integrated with an automated sample delivery system. ? Patented, reusable sensor chip surfaces available in a variety of surface chemistries. ? Assay temperature range of 4 to 45?C for thermodynamic analysis. ? Integrated buffer degasser for robust assay data quality at elevated temperatures, and for longer unattended runs. ? Buffer switching capacity for use of multiple buffers within a single run. ? Evaluation software capable of global and statistical analysis of data for the following applications: specificity, kinetic, steady-state, thermodynamics and concentration. ? Surface plasmon resonance is the only technology that provides information about binding specificity, active concentration, kinetic rate constants, affinity and thermodynamics in a single instrument platform. Molecular interactions are monitored in real time at concentrations ranging from picomolar to millimolar. Typical working ranges for association constant (Ka): 103107 M-1 S-1, dissociation rate constant (Kd): 5x10-60.5 S-1, affinity: 1042x1010 M-1, concentration range: 10-310-11 M. It has the a bility to detect an extremely wide range of molecular masses ranging from ca. 150 Da to the size of bacteriophage particles or whole cells; ? It is the only technology offering a full range of sensor surfaces, including dextran, which means a wider range of molecules can be characterized, starting from small molecules. Many of these sensor surfaces are based on patented dextran surface chemis try proven to mimic a solution environment--including short dextran, flat carboxyl, low charge dextran. The sensor chip surfaces available support many established and proven covalent immobilization chemistries and capture systems. Available hydrophobic an d lipophilic sensor chips provide methods for working with lipids. Streptavidin sensor chips capture biotinylated molecules such as oligonucleotides, RNA and DNA, and NTA sensor chips support work with histidine tagged proteins; ? It is the only biosensor whose chip surface is reusable for multiple (often hundreds) of sample cycles by automatic injection of a regeneration solution between sample injections; ? Only the Biacore T100 incorporates a single sensor surface overlaid by four flow cells, each with a volume of 50nL. One flow cell can be used as a true reference during a sample injection. Typical injection volumes of 50  250?L saves on reagent consumption. During the injection the proprie tary microfluidics system, automatically delivers sample to the chip surface at precisely controlled time and equal concentration across all the flow cells specified in the method;
 

Place of Performance

Address: US Army Medical Research Acquisition Activity ATTN: MCMR-AAA, 820 Chandler Street Frederick MD

Zip Code: 21702-5014

Country: US
 

Record

SN01179263-W 20061111/061109221029 (fbodaily.com)
 

Source

FedBizOpps Link to This Notice
(may not be valid after Archive Date)

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