MODIFICATION
A -- Novel Technologies in Newborn Screening
- Notice Date
- 11/23/2005
- Notice Type
- Modification
- NAICS
- 541710
— Research and Development in the Physical, Engineering, and Life Sciences
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Institute of Child Health and Human Development, Contracts Management Branch 6100 Executive Blvd., Suite 7A07, MSC7510, Bethesda, MD, 20892-7510
- ZIP Code
- 20892-7510
- Solicitation Number
- NICHD-2006-01
- Response Due
- 3/13/2006
- Archive Date
- 3/28/2006
- Point of Contact
- Paul Duska, Contracting Officer, Phone 301-435-6955, Fax 301-402-3676, - Paul Duska, Contracting Officer, Phone 301-435-6955, Fax 301-402-3676,
- E-Mail Address
-
pd28n@nih.gov, pd28n@nih.gov
- Description
- The following text is modified to replace quotation marks that the internet software converted into question marks. The quotation marks are now replaced with single quote marks; the text is otherwise unchanged. The National Institute of Child Health and Human Development (NICHD) is planning to award a contract for the development of multiplexed screening assays that can be automated and utilized in a high throughput environment for newborn screening. The intended goal of the contract is to develop a screening technology platform of components based on a range of technologies that include, but are not limited to: chip technologies, microbead technologies, nanotechnologies, microfluidics, DNA assays, biophysical assays, and technologies based on RNA or proteomics. Offerors should propose a technology that tests for all conditions or an integrated platform of complementary technologies that can accomplish the screening of groups of conditions, which can be utilized by State Newborn Screening Programs or that can be adapted by large commercial laboratories involved in newborn screening. The conditions to be addressed might include inborn errors of metabolism, hematological disorders, congenital endocrinopathies, lysosomal storage diseases, immunodeficiency disorders, chromosomal disorders (e.g., fragile X syndrome), or those characterized through control mechanisms of gene expression (e.g., epigenetics). NICHD prefers that the technology platforms integrate the testing of multiple groups of conditions and link to newborn screening informatic systems. NICHD is particularly interested in technologies that screen for 'high priority' conditions with current or promising effective therapeutic interventions (e.g., Duchenne muscular dystrophy, spinal muscular atrophy, severe combined immunodeficiency, the lysosomal storage diseases ? Pompe disease, Fabry disease, Krabbe disease and the mucopolysaccharidoses), which presently lack sensitive and specific tests. A report, 'Newborn Screening: Toward a Uniform Screening Panel and System' (http://mchb.hrsa.gov/screening), which the Maternal and Child Health Bureau, Health Resources and Services Administration sponsored and the American College of Medical Genetics developed, identifies some of these 'high priority' conditions. In this solicitation, a 'high priority' condition is a condition for which the development of a screening test would make the condition amenable to newborn screening. Proposals in responses to this solicitation should address the following issues surrounding the development of the technologies: (1) its utility for newborn screening for conditions currently screened within the United States (including its predictive value, sensitivity and specificity); (2) its efficacy of newborn screening for conditions currently screened, comparing the new technology with traditional or alternative techniques; (3) its flexibility (i.e., ability of the technology to facilitate expansion of its multiplexing capabilities to include new conditions in the future); (4) its potential for streamlining and full automation for population screening; (5) its appropriateness, based on the framework of established screening procedures; and, (6) its potential risks and benefits (e.g., ability to detect genetic variance, clinical heterogeneity, carrier status). The required service is defined as code 541710 under the North American Industry Classification System (NAICS). The Request for Proposal (RFP) will be available on or about December 12, 2005 through the web site at http://FedBizOpps.gov (FBO). This acquisition is NOT set-aside for small businesses, i.e., all capable organizations are invited to submit proposals. While this acquisition is being conducted using full and open competition, proposals must include maximum utilization of small business subcontracting, as appropriate. Questions should be sent in writing to Paul J. Duska, Contracting Officer, at duskap@mail.nih.gov , or addressed to the same at NICHD, CMB, Executive Building, Suite 7A07, 6100 EXECUTIVE BLVD MSC 7510, BETHESDA MD 20892-7510 ( if sending by overnight carrier-- 6100 Executive Boulevard, Suite 7A07, Rockville, Maryland 20852), by fax to 301-402-3676. Responses to the RFP must be submitted within 90 days after the date of issue, to: Paul J. Duska, Contracting Officer, NICHD, CMB, 6100 Building, suite 7A07, 6100 EXECUTIVE BLVD MSC 7510, BETHESDA MD 20892-7510 (if sending by overnight carrier, use 6100 Executive Blvd., Suite 7A07, Rockville, MD 20852). Electronic copies will not be accepted. The reference number to be used for this announcement is: RFP NICHD-2005-12. All correspondence must cite the reference number as provided.
- Record
- SN00936887-W 20051125/051123211713 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
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