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FBO DAILY ISSUE OF JULY 03, 2004 FBO #0950
SOLICITATION NOTICE

D -- Procurement of a Screening Samples Database and Sample Purchasing Service

Notice Date

7/1/2004
 

Notice Type

Solicitation Notice
 

NAICS

541511 — Custom Computer Programming Services
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
 

ZIP Code

20852
 

Solicitation Number

NCI-40092-NG
 

Response Due

7/12/2004
 

Archive Date

7/27/2004
 

Point of Contact

Malinda Holdcraft, Purchasing Agent, Phone (301) 402-4509, Fax (301) 402-4513, - Caren Rasmussen, Lead Contract Specialist, Phone (301) 402-4509, Fax (301) 402-4513,
 

E-Mail Address

holdcram@exchange.nih.gov, cr214i@nih.gov
 

Small Business Set-Aside

Total Small Business
 

Description

The National Institutes of Health (NIH), National Cancer Institute (NCI), Office of Science and Technology Partnerships, (OSTP), plans to obtain a current and comprehensive database of commercially accessible drug discovery screening compounds including access to a sample procurement service and license, to be made available to NIH users with ChemNavigator, 6126 Nancy Ridge Drive, Suite 117, San Diego, California 92121. This requirement will be procured in accordance with FAR Part 12. The North American Industry Classification System Code (NAICS) is 541511 and the Business Size Standard is $21M. This procurement is set aside for a Total one-hundred (100%) Small Business. Period of performance; Firm Fixed Price contract: License to institution-wide use of the 2-D chemical structure from the iResearch Library; Base Year - July 2004 - July 2005 with two (2) 12 month option years. In addition an Indefinite Delivery - Indefinite Quantity type contract will also be issued for compounds, chemistry, proteins, samples, silico screening, services, and procurement type services and fees. Researchers at NCI and NIH are increasingly screening small-molecule samples against specific molecular targets - mostly proteins - in an effort to find inhibitors (or sometimes activators), both as probes of the underlying biological mechanisms and as potential lead compounds in the fight against diseases such as cancer and AIDS. The importance of this approach, and, concomitantly, the need for large collections of small molecules available to NIH researchers has been recognized by NIH?s leadership, which has found its expression in, e.g., the ?Molecular Libraries? NIH RoadMap initiatives recently announced by NIH Director Dr. Elias Zerhouni. Notwithstanding the great benefits that will hopefully stem from these initiatives, it is nevertheless clear that availability of actual screening samples for NIH researchers in the context of an NIH RoadMap Molecular Library Repository is (a) still a few years away, and (b) will be limited to a relatively small subset of 500,000 to 1 million different samples even when it becomes available. In general, therefore, availability of screening samples from as wide a collection as possible and in a convenient manner for NIH researchers is currently not truly given. The current universe of screening samples available from commercial sources world-wide is more than 10 million and growing. These samples come from over 200 different manufacturers, many of which are located in Eastern Europe. It is technically and practically impossible for an individual researcher, or even an entire laboratory, to (a) obtain, standardize, combine, and search in the aggregate collection of, all these different supplier catalogs and databases, and (b), even if the former were possible, to place orders for, say, 100 samples coming from maybe twenty different suppliers located in the U.S., Canada, Russia, the Ukraine etc. A company has been founded after recognition of this unmet need in the market, which is similarly felt by pharmaceutical industry. ChemNavigator, Inc., aggregates the catalogs of screening samples from as many vendors world-wide as possible. It standardizes and curates the individual suppliers? databases, combines them into a large collection of unique structures, and makes this database (?iResearch Database?) of currently more than 10 million molecules available to its customers both through a web interface and in bulk format for in-house in silico screening. This service will be invaluable to NIH researchers, because it will make available the largest currently known collection of obtainable screening samples that was heretofore largely inaccessible for practical reasons. Furthermore, this resource is available now and does not need any lengthy development and ramp-up time. The ChemNavigator iResearch resource is unique in its ability to provide aggregate access to both structures and actual purchasable samples from the majority of available sources world-wide. It is the largest currently available collection of small-molecule screening samples. The iResearch Database currently contains more than 11 million unique compounds, with a growing tendency. ChemNavigator, Inc is the only source known to the NCI that can provide the iResearch Database and is the largest known database that can provide these unique compounds in one location. This is not a request for competitive quotation. However, if any interested party believes it can perform the above requirement, it may submit a statement of capabilities. The statement of capabilities and any other furnished information must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can perform this requirement. Capability statements must be received in the contracting office by 1:00 PM EST, July 12, 2004. If you have any questions they must be submitted in writing to Malinda Holdcraft, Purchasing Agent, at holdcram@exchange.nih.gov or by fax 301-402-4513. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. Solicitation number NCI- 40092-NG must be stated on all correspondence.
 

Place of Performance

Address: Bethesda, MD

Zip Code: 20892

Country: USA
 

Record

SN00613719-W 20040703/040701211845 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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