SOURCES SOUGHT
A -- Coronary Artery Risk Development In Young Adults-Computed Tomography Reading Center
- Notice Date
- 9/24/2002
- Notice Type
- Sources Sought
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute, Contracts Operations Branch 6701 Rockledge Dr RKL2/6100 MSC 7902, Bethesda, MD, 20892-7902
- ZIP Code
- 20892-7902
- Solicitation Number
- Reference-Number-NHLBI-HC-0405CT
- Point of Contact
- Vivian Lucas, Contract Specialist, Phone 301-435-0345, Fax 301-480-3430, - Cheryl Jennings, Contracting Officer, Phone (301) 435-0345, Fax (301) 480-3430,
- E-Mail Address
-
lucasv@nhlbi.nih.gov, cj19f@nih.gov
- Description
- The National Heart, Lung, and Blood Institute (NHLBI) has a requirement for a Computed Tomography Reading Center (CTRC) to read scans performed as part of the renewal of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Small business firms having demonstrated research and development capabilities for collaboration in the coordination and implementation of designing a cardiovascular study protocol and the capability of reading, and performing information abstraction to assess coronary calcium for the study are invited to submit capabilities statements. CARDIA is a longitudinal cohort study designed to assess the development of CVD in men and women initially aged 18-30 years in four U.S. communities. In its year 20 examination, the study will assess measures of subclinical disease, or disease detected non-invasively before it has produced signs and symptoms. CARDIA includes a Coordinating Center and four Field Centers. The proposed renewal of the CARDIA has four primary objectives: a. Identify predictors of earlier development and more rapid progression of subclinical atherosclerosis. b. Assess racial differences in severity and progress of early subclinical disease to elucidate possible differences in CVD pathogenesis. c. Test whether inflammation precedes subclinical disease. d. Assess the roles of genetic variation and gene by environment interactions in early development and progress of subclinical diseases. Necessary functions of the CARDIA CTRC include the coordination, at the direction of the Steering Committee and in collaboration with CARDIA Coordinating and Field Centers, of the development of protocols for computed tomography (CT) examinations for coronary calcium at each Field Center, in CT reading and information abstraction at the Reading Center, in accordance with the study design. Train and certify Field Center technicians according to the scanning protocol. Train and certify CT readers at the Reading Center according to the reading and information abstraction protocol. Conduct a pilot test of the CT protocols, including Quality Control activities, during the protocol development/pilot testing phase, in collaboration with Field Centers and the Coordinating Center. Perform readings and information abstractions of CT measurements on approximately 3,300 studies during the 12-month examination period, from June 1, 2005 through May 30, 2006, and rereads for quality control during the examination. Participate in various other activities including participate in the Steering Committee, Imaging Committee, and other subcommittees as necessary, and participate in data analysis and preparation of reports and manuscripts using the CT data. Information should establish: (1) Professional qualifications, expertise, and experience of scientists and technical personnel in relevant areas including cardiac CT imaging, cardiovascular epidemiology, statistics and vascular biology. (2) Demonstrated capacity of individuals and the institutional support to perform the functions of a cardiac CT imaging reading center for a multi-center collaborative epidemiology study, including protocol development, information processing, and coding. (3) Availability and experience with facilities and equipment, including technical software and hardware to read cardiac CT images, and capability of transferring data between Field Centers and the Reading Center. (4) Evidence of ability to integrate potential advances in cardiac CT imaging technology into study protocol. (5) Evidence of the ability to assess and monitor quality control for obtaining and reading cardiac CT images. (6) Evidence of ability, software, and hardware for data management, including tracking of all Reading Center activities. (7) The firms status as a small business under NAICS Code 541710, Research and Development in the Physical, Engineering, and Life Sciences. This is not a RFP. No RFP is available. Three hard copies of the material requested above should be submitted or electronically to lucasv@nhlbi.nih.gov within 15 days from the publication of the CBD.
- Record
- SN00174517-W 20020926/020924213249 (fbodaily.com)
- Source
-
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