SOLICITATION NOTICE
A -- Exposure to Risk Monitor
- Notice Date
- 7/2/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Energy, Pacific Northwest National Laboratory - Battelle (DOE Contractor), PNNL Licensing, PO Box 999, MSIN K9-89, Richland, WA, 99352
- ZIP Code
- 99352
- Solicitation Number
- Reference-Number-11042
- Response Due
- 8/15/2002
- Archive Date
- 8/30/2002
- Point of Contact
- Connie Mitzel-Faulk, Licensing Staff, Phone (509) 375-6401, Fax (509) 375-6731, - Connie Mitzel-Faulk, Licensing Staff, Phone (509) 375-6401, Fax (509) 375-6731,
- E-Mail Address
-
technology@pnl.gov, technology@pnl.gov
- Description
- Pacific Northwest National Laboratory (PNNL), operated by Battelle Memorial Institute under contract to the U.S. Department of Energy, solicits interest from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. PNNL may also be available to licensee(s) to assist in further research and development of the technology under a sponsored research agreement or CRADA program. THE TECHNOLOGY: The Exposure-to-Risk Monitor (E2RM) is intended to monitor the exposure of workers exposed to hazardous chemicals by determining the amounts of chemicals in the workers? breath. E2RM is a system combining a breath inlet device with an ion trap mass spectrometer that is controlled by a personal computer with appropriate software. For most volatile organic chemicals (VOCs), the experimental detection limit is approximately 10 parts-per-billion (ppb). Once the concentration of the VOC and its metabolite is known, a physiologically based pharmacokinetic (PBPK) mathematical model is used to relate exposure levels to the amount of internal dose received and thus, the resulting health risk. The PBPK model describes how a compound gets into the body, where it goes within the body, how it breaks down, and how it exits the body. The software to run the PBPK model is part of the software loaded in the personal computer, so the analysis can be completed immediately. While other monitoring systems usually measure exposure to chemicals in air, the E2RM can determine actual dose from ingestion and skin absorption, as well as inhalation. Because the detection system is a full-scale ion trap mass spectrometer, the system can simultaneously track and identify multiple chemicals in the body. The E2RM system can also be used to readout personal chemical samplers using a special desorber unit designed to operate with the system. This method provides nearly immediate readout of the personal samplers as soon as field exposures are completed. Since the E2RM is field portable, rapid determination of exposure can be accomplished each time a worker leaves a hazardous environment. The system scans through the entire mass range every 1.5 seconds. Thus, the system can rapidly analyze the decay in concentration for several VOCs in the breath simultaneously. Field studies have been conducted using human volunteers with good results. Many laboratory studies have been conducted with animals to confirm experimental methods with the PBPK model. Chemical studies include trichloroethylene, carbon tetrachloride, benzene, toluene, and others. Please see: US Pat. No. 5,645,072. Please see: Toxicological Sciences, 2000, vol 56, 61. Please see: Inhalation Toxicology, 1996, vol 8, 521. NOTE: THIS IS NOT A PROCUREMENT. Any company interested in licensing this technology must respond with a letter of interest (may be submitted by e-mail) no later than 30 days from the publication date of this Notice summarizing the company?s business and technical expertise and motivation for pursuing this opportunity. Companies deemed appropriate will be provided with further information on the technology. Such information may require an executed Nondisclosure Agreement. Respondents wishing to enter into negotiations for a commercial license will be required to submit a business plan for the commercialization of the technology prior to licensee(s) selection and negotiations. Please send letters of interest to the attention of the POC identified within this Notice.
- Web Link
-
Link to FedBizOpps document.
(http://www.eps.gov/spg/DOE/PNNL/LIC/Reference-Number-11042/listing.html)
- Record
- SN00103898-F 20020704/020703042806 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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