SOLICITATION NOTICE
66 -- Confocal Microscope with 32 Channel Multi-Spectral Detector and NLO
- Notice Date
- 3/28/2002
- Notice Type
- Solicitation Notice
- Contracting Office
- Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Room 604, Rockville, MD, 20852
- ZIP Code
- 20852
- Solicitation Number
- NCI-RFQ-20034-NV
- Response Due
- 4/4/2002
- Archive Date
- 4/19/2002
- Point of Contact
- Deborah Moore, Purchasing Agent, Phone (301) 496-8609, Fax (301) 402-4513, - David Keefer, Contracting Officer, Phone (301) 435-3801, Fax (301) 480-0309,
- E-Mail Address
-
dm170b@nih.gov, dk63h@nih.gov
- Description
- The National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), Developmental Neural Plasticity Unit (DNP) plans to procure an LSM 510 META-NLO Laser Scanning Microscope system from Carl Zeiss Inc., Once Zeiss Drive, Thornwood, NY 10594. This Confocal Microscope with 32 channel multi-spectral detector and NLO will be an integral part of a two-photon laser scannning microscope. The DNP is currently engaged in the study of fundamental mechanisms that underlie the development and remodeling of neuronal circuits in the mammalian olfactory system. These studies use expressed fluorescent proteins (GFP, YFP, CFP, dsRed) in the olfactory system and will focus on imaging primary afferents as they converge and form synapses onto the olfactory bulbs. Since these fluorophores have highly overlapping emission spectra the ability to separate their individual fluorescent signals is critical to the outcome of the experiments. The ?META-Detector? developed and exclusively available through Carl Zeiss on its LSM 510 is specifically designed to distinguish overlapping emission spectra. The META uses an optical grating (prism) that separates the emitted light into multiple wavelengths and then detects this light through a 32 channel detector. The META system is able to discriminate the fluorescence signal produced by fluorophores with widely overlapping emission spectra (i.e. GFP, YFP, FITC). The system will include a 40mW argon laser (458, 488, and 514) and two helium neon lasers (543nm and 633 nm). This laser combination provides the excitation wavelengths needed to excite commonly used fluorophores. The system will include the non-linear optical elements (NLO) essential for coupling a femtosecond laser system (MIRA 900F from Coherent) giving the confocal multi-photon capability. The system has one META detector and a separate internal conventional PMT detector with independent pinhole as well as two external detectors for 2-photon sensitivity detector. The system also includes an Acousto Optical Modulator (AOM) which is essential for attenuation and precise wavelength selection of beam from the 2-photon laser system. This system is commercial as defined in FAR Part 2, and this acquisition is being made in accordance with the test program using simplified procedures for certain commercial items as authorized in FAR 13.5. Carl Zeiss Inc., is the only organization known to the NINDS researcher that has all the aforementioned features that are required and believed to be unique. This is not a request for competitive quotation. However, if any interested party believes it can meet the above requirement and the noted features, it may submit a statement of capabilities. The statement of capabilities and any other information furnished must be in writing and must contain material in sufficient detail to allow the NINDS research to determine if the party can perform this requirement. An original and one copy of the capability statements must be received in the contracting office by 2:30 p.m. EST, on April 4, 2002. All questions must be in writing and can be faxed to (301) 402-4513 or emailed to dm170b@nih.gov . It is the vendors responsibility to call (301) 402-4509 to insure questions have been received. A determination by the Government not to compete this proposed requirement based upon responses to this notice is solely within the discretion of the Government. Information received will be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect call will be accepted. NAICS 334516
- Place of Performance
- Address: 9000 Rockville Pike, Building 36
- Zip Code: 20892
- Zip Code: 20892
- Record
- SN00049580-W 20020330/020328213156 (fbodaily.com)
- Source
-
FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)
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